| http://purl.uniprot.org/citations/29466725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29466725 | http://www.w3.org/2000/01/rdf-schema#comment | "Spatial relationships between Cav channels and release sensors at active zones (AZs) are a major determinant of synaptic fidelity. They are regulated developmentally, but the underlying molecular mechanisms are largely unclear. Here, we show that Munc13-3 regulates the density of Cav2.1 and Cav2.2 channels, alters the localization of Cav2.1, and is required for the development of tight, nanodomain coupling at parallel-fiber AZs. We combined EGTA application and Ca2+-channel pharmacology in electrophysiological and two-photon Ca2+ imaging experiments with quantitative freeze-fracture immunoelectron microscopy and mathematical modeling. We found that a normally occurring developmental shift from release being dominated by Ca2+ influx through Cav2.1 and Cav2.2 channels with domain overlap and loose coupling (microdomains) to a nanodomain Cav2.1 to sensor coupling is impaired in Munc13-3-deficient synapses. Thus, at AZs lacking Munc13-3, release remained triggered by Cav2.1 and Cav2.2 microdomains, suggesting a critical role of Munc13-3 in the formation of release sites with calcium channel nanodomains."xsd:string |
| http://purl.uniprot.org/citations/29466725 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2018.02.010"xsd:string |
| http://purl.uniprot.org/citations/29466725 | http://purl.uniprot.org/core/author | "Watanabe M."xsd:string |
| http://purl.uniprot.org/citations/29466725 | http://purl.uniprot.org/core/author | "Schmidt H."xsd:string |
| http://purl.uniprot.org/citations/29466725 | http://purl.uniprot.org/core/author | "Jordan J."xsd:string |
| http://purl.uniprot.org/citations/29466725 | http://purl.uniprot.org/core/author | "Bank J."xsd:string |
| http://purl.uniprot.org/citations/29466725 | http://purl.uniprot.org/core/author | "Kulik A."xsd:string |
| http://purl.uniprot.org/citations/29466725 | http://purl.uniprot.org/core/author | "Heckmann M."xsd:string |
| http://purl.uniprot.org/citations/29466725 | http://purl.uniprot.org/core/author | "Loreth D."xsd:string |
| http://purl.uniprot.org/citations/29466725 | http://purl.uniprot.org/core/author | "Eilers J."xsd:string |
| http://purl.uniprot.org/citations/29466725 | http://purl.uniprot.org/core/author | "Bornschein G."xsd:string |
| http://purl.uniprot.org/citations/29466725 | http://purl.uniprot.org/core/author | "Baur D."xsd:string |
| http://purl.uniprot.org/citations/29466725 | http://purl.uniprot.org/core/author | "Kusch V."xsd:string |
| http://purl.uniprot.org/citations/29466725 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29466725 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/29466725 | http://purl.uniprot.org/core/pages | "1965-1973"xsd:string |
| http://purl.uniprot.org/citations/29466725 | http://purl.uniprot.org/core/title | "Munc13-3 Is Required for the Developmental Localization of Ca2+ Channels to Active Zones and the Nanopositioning of Cav2.1 Near Release Sensors."xsd:string |
| http://purl.uniprot.org/citations/29466725 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/29466725 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29466725 |
| http://purl.uniprot.org/citations/29466725 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29466725 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWR0-mappedCitation-29466725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29466725 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWZ5-mappedCitation-29466725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29466725 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SQZ2-mappedCitation-29466725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29466725 |
| http://purl.uniprot.org/uniprot/#_A0A571BE75-mappedCitation-29466725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29466725 |