| http://purl.uniprot.org/citations/29472843 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29472843 | http://www.w3.org/2000/01/rdf-schema#comment | "Injury to the adult central nervous systems (CNS) can result in severe long-term disability because damaged CNS connections fail to regenerate after trauma. Identification of regulators that enhance the intrinsic growth capacity of severed axons is a first step to restore function. Here, we conducted a gain-of-function genetic screen in Drosophila to identify strong inducers of axonal growth after injury. We focus on a novel axis the Down Syndrome Cell Adhesion Molecule (Dscam1), the de-ubiquitinating enzyme Fat Facets (Faf)/Usp9x and the Jun N-Terminal Kinase (JNK) pathway transcription factor Kayak (Kay)/Fos. Genetic and biochemical analyses link these genes in a common signaling pathway whereby Faf stabilizes Dscam1 protein levels, by acting on the 3'-UTR of its mRNA, and Dscam1 acts upstream of the growth-promoting JNK signal. The mammalian homolog of Faf, Usp9x/FAM, shares both the regenerative and Dscam1 stabilizing activities, suggesting a conserved mechanism."xsd:string |
| http://purl.uniprot.org/citations/29472843 | http://purl.org/dc/terms/identifier | "doi:10.3389/fncel.2017.00416"xsd:string |
| http://purl.uniprot.org/citations/29472843 | http://purl.uniprot.org/core/author | "Holt M."xsd:string |
| http://purl.uniprot.org/citations/29472843 | http://purl.uniprot.org/core/author | "Yan J."xsd:string |
| http://purl.uniprot.org/citations/29472843 | http://purl.uniprot.org/core/author | "Nicolas M."xsd:string |
| http://purl.uniprot.org/citations/29472843 | http://purl.uniprot.org/core/author | "Hassan B.A."xsd:string |
| http://purl.uniprot.org/citations/29472843 | http://purl.uniprot.org/core/author | "Koch M."xsd:string |
| http://purl.uniprot.org/citations/29472843 | http://purl.uniprot.org/core/author | "Claeys A."xsd:string |
| http://purl.uniprot.org/citations/29472843 | http://purl.uniprot.org/core/author | "Morgan M.J."xsd:string |
| http://purl.uniprot.org/citations/29472843 | http://purl.uniprot.org/core/author | "Schmucker D."xsd:string |
| http://purl.uniprot.org/citations/29472843 | http://purl.uniprot.org/core/author | "de Geest N."xsd:string |
| http://purl.uniprot.org/citations/29472843 | http://purl.uniprot.org/core/author | "Erfurth M.L."xsd:string |
| http://purl.uniprot.org/citations/29472843 | http://purl.uniprot.org/core/author | "Zschaetzsch M."xsd:string |
| http://purl.uniprot.org/citations/29472843 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29472843 | http://purl.uniprot.org/core/name | "Front Cell Neurosci"xsd:string |
| http://purl.uniprot.org/citations/29472843 | http://purl.uniprot.org/core/pages | "416"xsd:string |
| http://purl.uniprot.org/citations/29472843 | http://purl.uniprot.org/core/title | "A Fat-Facets-Dscam1-JNK Pathway Enhances Axonal Growth in Development and after Injury."xsd:string |
| http://purl.uniprot.org/citations/29472843 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/29472843 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29472843 |
| http://purl.uniprot.org/citations/29472843 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29472843 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFX7-mappedCitation-29472843 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29472843 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KES0-mappedCitation-29472843 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29472843 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFF0-mappedCitation-29472843 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29472843 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DHD8-mappedCitation-29472843 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29472843 |