| http://purl.uniprot.org/citations/29474739 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29474739 | http://www.w3.org/2000/01/rdf-schema#comment | "Bone formation and bone homeostasis are energy-expensive processes. How they are being regulated by energy needs is not completely understood. This is of high clinical importance because diabetic-induced bone loss is common whereas the underlying mechanisms are unclear. Here, we show that Mst1/2 are important regulators for glucose uptake during osteoblast differentiation. Genetically removal of both Mst1/2 kinases simultaneously in mice in early and mature osteoblasts inhibits bone formation and bone remodeling, respectively. We found that the activity of Mst1/2 kinases is sensitive to glucose levels, and in turn, regulates glucose uptake by stabilizing key glucose transporter Glut1. In the absence of Mst1/2 kinases, Glut1 expression is loss and results in AMP-dependent protein kinase (AMPK) activation and subsequent proteasomal degradation of Runx2. The streptozotocin (STZ)-induced diabetic mouse model also recapitulates similar changes in the bone tissues. In addition, Glut1 expression regulated by Mst1/2 kinases is independent of Yap/Taz expression. Our results unravel new mechanistic insights into the orchestration of glucose level and bone homeostasis. © 2018 American Society for Bone and Mineral Research."xsd:string |
| http://purl.uniprot.org/citations/29474739 | http://purl.org/dc/terms/identifier | "doi:10.1002/jbmr.3413"xsd:string |
| http://purl.uniprot.org/citations/29474739 | http://purl.uniprot.org/core/author | "Deng Y."xsd:string |
| http://purl.uniprot.org/citations/29474739 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/29474739 | http://purl.uniprot.org/core/author | "Feng B."xsd:string |
| http://purl.uniprot.org/citations/29474739 | http://purl.uniprot.org/core/author | "Mak K.K."xsd:string |
| http://purl.uniprot.org/citations/29474739 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29474739 | http://purl.uniprot.org/core/name | "J Bone Miner Res"xsd:string |
| http://purl.uniprot.org/citations/29474739 | http://purl.uniprot.org/core/pages | "1183-1195"xsd:string |
| http://purl.uniprot.org/citations/29474739 | http://purl.uniprot.org/core/title | "Mst1/2 Kinases Modulate Glucose Uptake for Osteoblast Differentiation and Bone Formation."xsd:string |
| http://purl.uniprot.org/citations/29474739 | http://purl.uniprot.org/core/volume | "33"xsd:string |
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