| http://purl.uniprot.org/citations/29474929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29474929 | http://www.w3.org/2000/01/rdf-schema#comment | "Alternative splicing has been widely demonstrated to function as pivotal regulation in specifying cellular fates and biological functions. The relative expression or cellular localization of a splicing factor constitutes an important mechanism in spatiotemporal programming of cell- and stage-specific splicing profiles. In this study, results of deep RNA-sequencing (RNA-Seq) analyses first revealed the reprogrammed splicing profile and reduced expression of serine/arginine-rich splicing factor protein kinase 1 (SRPK1) throughout the development of brown adipose tissue (BAT). A gradual increase in the exon 10-skipped SRPK1 transcript, a potential target of a nonsense-mediated decay (NMD) mechanism, was noted during brown adipogenesis. Elevated RBM4a constituted the regulatory mechanism that led to skipping of SRPK1 exon 10. Moreover, brown adipogenesis-induced upregulation of microRNA (miR)-485 interfered with SRPK1 expression by targeting its 3'-untranslated region (UTR). Depletion of endogenous SRPK1 enhanced the development of C3H10T1/2 cells toward brown adipocytes. Taking our results together, multiple post-transcriptional regulations reduced SRPK1 expression, which subsequently affected brown adipogenesis."xsd:string |
| http://purl.uniprot.org/citations/29474929 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbalip.2018.02.004"xsd:string |
| http://purl.uniprot.org/citations/29474929 | http://purl.uniprot.org/core/author | "Lin J.C."xsd:string |
| http://purl.uniprot.org/citations/29474929 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29474929 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta Mol Cell Biol Lipids"xsd:string |
| http://purl.uniprot.org/citations/29474929 | http://purl.uniprot.org/core/pages | "503-514"xsd:string |
| http://purl.uniprot.org/citations/29474929 | http://purl.uniprot.org/core/title | "Multi-posttranscriptional regulations lessen the repressive effect of SRPK1 on brown adipogenesis."xsd:string |
| http://purl.uniprot.org/citations/29474929 | http://purl.uniprot.org/core/volume | "1863"xsd:string |
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