| http://purl.uniprot.org/citations/29477340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29477340 | http://www.w3.org/2000/01/rdf-schema#comment | "Successful fertilization requires that sperm are activated prior to contacting an oocyte. In C. elegans, this activation process, called spermiogenesis, transforms round immobile spermatids into motile, fertilization-competent spermatozoa. We describe the phenotypic and genetic characterization of spe-43, a new component of the spe-8 pathway, which is required for spermiogenesis in hermaphrodites; spe-43 hermaphrodites are self-sterile, while spe-43 males show wild-type fertility. When exposed to Pronase to activate sperm in vitro, spe-43 spermatids form long rigid spikes radiating outward from the cell periphery instead of forming a motile pseudopod, indicating that spermiogenesis initiates but is not completed. Using a combination of recombinant and deletion mapping and whole genome sequencing, we identified F09E8.1 as spe-43. SPE-43 is predicted to exist in two isoforms; one isoform appears to be a single-pass transmembrane protein while the other is predicted to be a secreted protein. SPE-43 can bind to other known sperm proteins, including SPE-4 and SPE-29, which are known to impact spermiogenesis. In summary, we have identified a membrane protein that is present in C. elegans sperm and is required for sperm activation via the hermaphrodite activation signal."xsd:string |
| http://purl.uniprot.org/citations/29477340 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2018.02.013"xsd:string |
| http://purl.uniprot.org/citations/29477340 | http://purl.uniprot.org/core/author | "Mendez E."xsd:string |
| http://purl.uniprot.org/citations/29477340 | http://purl.uniprot.org/core/author | "Singson A."xsd:string |
| http://purl.uniprot.org/citations/29477340 | http://purl.uniprot.org/core/author | "Stanfield G.M."xsd:string |
| http://purl.uniprot.org/citations/29477340 | http://purl.uniprot.org/core/author | "Parry J."xsd:string |
| http://purl.uniprot.org/citations/29477340 | http://purl.uniprot.org/core/author | "Gu S.G."xsd:string |
| http://purl.uniprot.org/citations/29477340 | http://purl.uniprot.org/core/author | "Druzhinina M."xsd:string |
| http://purl.uniprot.org/citations/29477340 | http://purl.uniprot.org/core/author | "Ni J.Z."xsd:string |
| http://purl.uniprot.org/citations/29477340 | http://purl.uniprot.org/core/author | "Krauchunas A.R."xsd:string |
| http://purl.uniprot.org/citations/29477340 | http://purl.uniprot.org/core/author | "Mulia A."xsd:string |
| http://purl.uniprot.org/citations/29477340 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29477340 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/29477340 | http://purl.uniprot.org/core/pages | "75-83"xsd:string |
| http://purl.uniprot.org/citations/29477340 | http://purl.uniprot.org/core/title | "spe-43 is required for sperm activation in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/29477340 | http://purl.uniprot.org/core/volume | "436"xsd:string |
| http://purl.uniprot.org/citations/29477340 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29477340 |
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