| http://purl.uniprot.org/citations/29480805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29480805 | http://www.w3.org/2000/01/rdf-schema#comment | "The Drosophila Pan Gu (PNG) kinase complex regulates hundreds of maternal mRNAs that become translationally repressed or activated as the oocyte transitions to an embryo. In a previous paper (Hara et al., 2017), we demonstrated PNG activity is under tight developmental control and restricted to this transition. Here, examination of PNG specificity showed it to be a Thr-kinase yet lacking a clear phosphorylation site consensus sequence. An unbiased biochemical screen for PNG substrates identified the conserved translational repressor Trailer Hitch (TRAL). Phosphomimetic mutation of the PNG phospho-sites in TRAL reduced its ability to inhibit translation in vitro. In vivo, mutation of tral dominantly suppressed png mutants and restored Cyclin B protein levels. The repressor Pumilio (PUM) has the same relationship with PNG, and we also show that PUM is a PNG substrate. Furthermore, PNG can phosphorylate BICC and ME31B, repressors that bind TRAL in cytoplasmic RNPs. Therefore, PNG likely promotes translation at the oocyte-to-embryo transition by phosphorylating and inactivating translational repressors."xsd:string |
| http://purl.uniprot.org/citations/29480805 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.33150"xsd:string |
| http://purl.uniprot.org/citations/29480805 | http://purl.uniprot.org/core/author | "Lourido S."xsd:string |
| http://purl.uniprot.org/citations/29480805 | http://purl.uniprot.org/core/author | "Turk B.E."xsd:string |
| http://purl.uniprot.org/citations/29480805 | http://purl.uniprot.org/core/author | "Lou H.J."xsd:string |
| http://purl.uniprot.org/citations/29480805 | http://purl.uniprot.org/core/author | "Hara M."xsd:string |
| http://purl.uniprot.org/citations/29480805 | http://purl.uniprot.org/core/author | "Petrova B."xsd:string |
| http://purl.uniprot.org/citations/29480805 | http://purl.uniprot.org/core/author | "Orr-Weaver T.L."xsd:string |
| http://purl.uniprot.org/citations/29480805 | http://purl.uniprot.org/core/author | "Kashevsky H."xsd:string |
| http://purl.uniprot.org/citations/29480805 | http://purl.uniprot.org/core/author | "Von Stetina J.R."xsd:string |
| http://purl.uniprot.org/citations/29480805 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29480805 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/29480805 | http://purl.uniprot.org/core/pages | "e33150"xsd:string |
| http://purl.uniprot.org/citations/29480805 | http://purl.uniprot.org/core/title | "Identification of PNG kinase substrates uncovers interactions with the translational repressor TRAL in the oocyte-to-embryo transition."xsd:string |
| http://purl.uniprot.org/citations/29480805 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/29480805 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29480805 |
| http://purl.uniprot.org/citations/29480805 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29480805 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFX7-mappedCitation-29480805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29480805 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFF0-mappedCitation-29480805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29480805 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K612-mappedCitation-29480805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29480805 |
| http://purl.uniprot.org/uniprot/#_M9NFR3-mappedCitation-29480805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29480805 |
| http://purl.uniprot.org/uniprot/#_E2QCR4-mappedCitation-29480805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29480805 |
| http://purl.uniprot.org/uniprot/#_M9PCB7-mappedCitation-29480805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29480805 |
| http://purl.uniprot.org/uniprot/#_M9PF14-mappedCitation-29480805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29480805 |