http://purl.uniprot.org/citations/29483614 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/29483614 | http://www.w3.org/2000/01/rdf-schema#comment | "Associations between human leukocyte antigen (HLA) variants and chlamydia-related outcomes have been inconsistent. We previously identified HLA-DQB1*06 as a risk marker for chlamydia reinfection in a cohort of predominately HIV-infected adolescents. As chlamydia reinfection can lead to reproductive complications, validation of this finding in HIV-seronegative women may help reveal the underlying biology. We performed HLA-DQB1 genotyping in HIV-seronegative, chlamydia-infected African American women who were evaluated for reinfection at 3- and 6-month visits after treatment. Of 185 evaluable women for whom HLA-DQB1 genotyping was performed, only HLA-DQB1*06 was associated with chlamydia reinfection (Pā=ā0.009), with no evidence of a dose-response effect for this allele. African American women with HLA-DQB1*06 may warrant more frequent chlamydia screening. More comprehensive genotyping of HLA class II and neighboring genes is needed to establish whether HLA-DQB1*06 is a causal variant for chlamydia reinfection or a surrogate for other causal variants in the major histocompatibility complex."xsd:string |
http://purl.uniprot.org/citations/29483614 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41435-018-0014-3"xsd:string |
http://purl.uniprot.org/citations/29483614 | http://purl.uniprot.org/core/author | "Tang J."xsd:string |
http://purl.uniprot.org/citations/29483614 | http://purl.uniprot.org/core/author | "Brown L."xsd:string |
http://purl.uniprot.org/citations/29483614 | http://purl.uniprot.org/core/author | "Olson K.M."xsd:string |
http://purl.uniprot.org/citations/29483614 | http://purl.uniprot.org/core/author | "Geisler W.M."xsd:string |
http://purl.uniprot.org/citations/29483614 | http://purl.uniprot.org/core/author | "Press C.G."xsd:string |
http://purl.uniprot.org/citations/29483614 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
http://purl.uniprot.org/citations/29483614 | http://purl.uniprot.org/core/name | "Genes Immun"xsd:string |
http://purl.uniprot.org/citations/29483614 | http://purl.uniprot.org/core/pages | "69-73"xsd:string |
http://purl.uniprot.org/citations/29483614 | http://purl.uniprot.org/core/title | "HLA-DQB1*06 is a risk marker for chlamydia reinfection in African American women."xsd:string |
http://purl.uniprot.org/citations/29483614 | http://purl.uniprot.org/core/volume | "20"xsd:string |
http://purl.uniprot.org/citations/29483614 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29483614 |
http://purl.uniprot.org/citations/29483614 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29483614 |
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