| http://purl.uniprot.org/citations/29488625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29488625 | http://www.w3.org/2000/01/rdf-schema#comment | "Although previous reports suggest that tumor-induced myeloid-derived suppressor cells (MDSC) inhibit T cells by L-arginine depletion through arginase-1 activity, we herein show that arginase-1 is neither inherently expressed in MDSC nor required for MDSC-mediated inhibition. Employing Percoll density gradients, large expansions of MDSC in the bone marrow of tumor-bearing mice were isolated and demonstrated potent inhibition in T-cell proliferation activated by TCR-ligation, Concanavalin A, PMA plus ionomycin, or IL-2. Despite demonstrating characteristic immunosuppressive capacity, these MDSC exhibit no arginase-1 expression and/or exert their inhibitory effects independent of arginase-1 activity. However, arginase-1 expression in MDSC can be induced by exposure to TCR-activated T cells or their culture medium, but not T cells activated by other means or growing tumor cells. Further investigation reveals multiple cytokines secreted by TCR-activated T cells as orchestrating two signaling-relay axes, IL-6-to-IL-4 and GM-CSF/IL-4-to-IL-10, leading to arginase-1 expression in MDSC. Specifically, IL-6 signaling increases IL-4R, enabling IL-4 to induce arginase-1 expression; similarly, GM-CSF in concert with IL-4 induces IL-10R, allowing IL-10-mediated induction. Surprisingly, our study indicates that induction of arginase-1 expression is not conducive to the critical MDSC-mediated inhibition toward T cells, which is rather dependent on direct cell contacts undiminished by PD-L1 blockade or SIRPα deficiency."xsd:string |
| http://purl.uniprot.org/citations/29488625 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201747355"xsd:string |
| http://purl.uniprot.org/citations/29488625 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/29488625 | http://purl.uniprot.org/core/author | "Liang H."xsd:string |
| http://purl.uniprot.org/citations/29488625 | http://purl.uniprot.org/core/author | "Shi L."xsd:string |
| http://purl.uniprot.org/citations/29488625 | http://purl.uniprot.org/core/author | "Xiong L."xsd:string |
| http://purl.uniprot.org/citations/29488625 | http://purl.uniprot.org/core/author | "Bian Z."xsd:string |
| http://purl.uniprot.org/citations/29488625 | http://purl.uniprot.org/core/author | "Zen K."xsd:string |
| http://purl.uniprot.org/citations/29488625 | http://purl.uniprot.org/core/author | "Venkataramani M."xsd:string |
| http://purl.uniprot.org/citations/29488625 | http://purl.uniprot.org/core/author | "Culpepper C."xsd:string |
| http://purl.uniprot.org/citations/29488625 | http://purl.uniprot.org/core/author | "Kidder K."xsd:string |
| http://purl.uniprot.org/citations/29488625 | http://purl.uniprot.org/core/author | "Abdelaal A.M."xsd:string |
| http://purl.uniprot.org/citations/29488625 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29488625 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/29488625 | http://purl.uniprot.org/core/pages | "1046-1058"xsd:string |
| http://purl.uniprot.org/citations/29488625 | http://purl.uniprot.org/core/title | "Arginase-1 is neither constitutively expressed in nor required for myeloid-derived suppressor cell-mediated inhibition of T-cell proliferation."xsd:string |
| http://purl.uniprot.org/citations/29488625 | http://purl.uniprot.org/core/volume | "48"xsd:string |
| http://purl.uniprot.org/citations/29488625 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29488625 |
| http://purl.uniprot.org/citations/29488625 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29488625 |
| http://purl.uniprot.org/uniprot/#_Q61176-mappedCitation-29488625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29488625 |
| http://purl.uniprot.org/uniprot/#_Q8K3K5-mappedCitation-29488625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29488625 |
| http://purl.uniprot.org/uniprot/Q61176 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29488625 |
| http://purl.uniprot.org/uniprot/Q8K3K5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29488625 |