| http://purl.uniprot.org/citations/29490264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29490264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29490264 | http://www.w3.org/2000/01/rdf-schema#comment | "Altering AMPA receptor (AMPAR) content at synapses is a key mechanism underlying the regulation of synaptic strength during learning and memory. Previous work demonstrated that SynDIG1 (synapse differentiation-induced gene 1) encodes a transmembrane AMPAR-associated protein that regulates excitatory synapse strength and number. Here we show that the related protein SynDIG4 (also known as Prrt1) modifies AMPAR gating properties in a subunit-dependent manner. Young SynDIG4 knockout (KO) mice have weaker excitatory synapses, as evaluated by immunocytochemistry and electrophysiology. Adult SynDIG4 KO mice show complete loss of tetanus-induced long-term potentiation (LTP), while mEPSC amplitude is reduced by only 25%. Furthermore, SynDIG4 KO mice exhibit deficits in two independent cognitive assays. Given that SynDIG4 colocalizes with the AMPAR subunit GluA1 at non-synaptic sites, we propose that SynDIG4 maintains a pool of extrasynaptic AMPARs necessary for synapse development and function underlying higher-order cognitive plasticity."xsd:string |
| http://purl.uniprot.org/citations/29490264 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2018.02.026"xsd:string |
| http://purl.uniprot.org/citations/29490264 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2018.02.026"xsd:string |
| http://purl.uniprot.org/citations/29490264 | http://purl.uniprot.org/core/author | "Diaz E."xsd:string |
| http://purl.uniprot.org/citations/29490264 | http://purl.uniprot.org/core/author | "Diaz E."xsd:string |
| http://purl.uniprot.org/citations/29490264 | http://purl.uniprot.org/core/author | "Hell J.W."xsd:string |
| http://purl.uniprot.org/citations/29490264 | http://purl.uniprot.org/core/author | "Hell J.W."xsd:string |
| http://purl.uniprot.org/citations/29490264 | http://purl.uniprot.org/core/author | "Crawley J.N."xsd:string |
| http://purl.uniprot.org/citations/29490264 | http://purl.uniprot.org/core/author | "Crawley J.N."xsd:string |
| http://purl.uniprot.org/citations/29490264 | http://purl.uniprot.org/core/author | "Speca D.J."xsd:string |
| http://purl.uniprot.org/citations/29490264 | http://purl.uniprot.org/core/author | "Speca D.J."xsd:string |
| http://purl.uniprot.org/citations/29490264 | http://purl.uniprot.org/core/author | "Stern-Bach Y."xsd:string |
| http://purl.uniprot.org/citations/29490264 | http://purl.uniprot.org/core/author | "Stern-Bach Y."xsd:string |
| http://purl.uniprot.org/citations/29490264 | http://purl.uniprot.org/core/author | "Matt L."xsd:string |
| http://purl.uniprot.org/citations/29490264 | http://purl.uniprot.org/core/author | "Matt L."xsd:string |
| http://purl.uniprot.org/citations/29490264 | http://purl.uniprot.org/core/author | "Chenaux G."xsd:string |
| http://purl.uniprot.org/citations/29490264 | http://purl.uniprot.org/core/author | "Chenaux G."xsd:string |
| http://purl.uniprot.org/citations/29490264 | http://purl.uniprot.org/core/author | "Haham T."xsd:string |
| http://purl.uniprot.org/citations/29490264 | http://purl.uniprot.org/core/author | "Haham T."xsd:string |
| http://purl.uniprot.org/citations/29490264 | http://purl.uniprot.org/core/author | "Kirk L.M."xsd:string |
| http://purl.uniprot.org/citations/29490264 | http://purl.uniprot.org/core/author | "Kirk L.M."xsd:string |
| http://purl.uniprot.org/citations/29490264 | http://purl.uniprot.org/core/author | "Plambeck K.E."xsd:string |
| http://purl.uniprot.org/citations/29490264 | http://purl.uniprot.org/core/author | "Plambeck K.E."xsd:string |