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http://purl.uniprot.org/citations/29490344http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/29490344http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

To investigate intraocular expression of COL7A1 and its protein product type VII collagen, particularly at the accommodation system.

Methods

Eyes from 26 human adult donors were used. COL7A1 expression was analyzed in ex vivo ciliary epithelium by microarray. Type VII collagen distribution was examined by Western blot analysis, immunohistochemistry. and immuno-electron microscopy.

Results

COL7A1 is expressed by pigmented and nonpigmented ciliary epithelia. Type VII collagen is distributed particularly at the strained parts of the accommodation system. Type VII collagen was associated with various basement membranes and with ciliary zonules. Anchoring fibrils were not visualized.

Conclusions

Type VII collagen distribution at strained areas suggests a supporting role in tissue integrity."xsd:string
http://purl.uniprot.org/citations/29490344http://purl.org/dc/terms/identifier"doi:10.1167/iovs.17-23425"xsd:string
http://purl.uniprot.org/citations/29490344http://purl.uniprot.org/core/author"Pas H.H."xsd:string
http://purl.uniprot.org/citations/29490344http://purl.uniprot.org/core/author"Kuijer R."xsd:string
http://purl.uniprot.org/citations/29490344http://purl.uniprot.org/core/author"Janssen S.F."xsd:string
http://purl.uniprot.org/citations/29490344http://purl.uniprot.org/core/author"Los L.I."xsd:string
http://purl.uniprot.org/citations/29490344http://purl.uniprot.org/core/author"Schol M."xsd:string
http://purl.uniprot.org/citations/29490344http://purl.uniprot.org/core/author"Van der Worp R.J."xsd:string
http://purl.uniprot.org/citations/29490344http://purl.uniprot.org/core/author"Wullink B."xsd:string
http://purl.uniprot.org/citations/29490344http://purl.uniprot.org/core/date"2018"xsd:gYear
http://purl.uniprot.org/citations/29490344http://purl.uniprot.org/core/name"Invest Ophthalmol Vis Sci"xsd:string
http://purl.uniprot.org/citations/29490344http://purl.uniprot.org/core/pages"1075-1083"xsd:string
http://purl.uniprot.org/citations/29490344http://purl.uniprot.org/core/title"Type VII Collagen in the Human Accommodation System: Expression in Ciliary Body, Zonules, and Lens Capsule."xsd:string
http://purl.uniprot.org/citations/29490344http://purl.uniprot.org/core/volume"59"xsd:string
http://purl.uniprot.org/citations/29490344http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/29490344
http://purl.uniprot.org/citations/29490344http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/29490344
http://purl.uniprot.org/uniprot/#_A9Z119-mappedCitation-29490344http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29490344
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http://purl.uniprot.org/uniprot/Q59F16http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/29490344
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http://purl.uniprot.org/uniprot/A9Z119http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/29490344