| http://purl.uniprot.org/citations/29500225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29500225 | http://www.w3.org/2000/01/rdf-schema#comment | "Atopic dermatitis is an allergic inflammatory skin disease characterized by the production of the type 2 cytokines in the skin by type 2 innate lymphoid cells (ILC2s) and T helper 2 (TH2) cells, and tissue eosinophilia. Using two distinct mouse models of atopic dermatitis, we show that expression of retinoid-related orphan receptor α (RORα) in skin-resident T regulatory cells (Tregs) is important for restraining allergic skin inflammation. In both models, targeted deletion of RORα in mouse Tregs led to exaggerated eosinophilia driven by interleukin-5 (IL-5) production by ILC2s and TH2 cells. Expression of RORα in skin-resident Tregs suppressed IL-4 expression and enhanced expression of death receptor 3 (DR3), which is the receptor for tumor necrosis factor (TNF) family cytokine, TNF ligand-related molecule 1 (TL1A), which promotes Treg functions. DR3 is expressed on both ILC2s and skin-resident Tregs Upon deletion of RORα in skin-resident Tregs, we found that Tregs were no longer able to sequester TL1A, resulting in enhanced ILC2 activation. We also documented higher expression of RORα in skin-resident Tregs than in peripheral blood circulating Tregs in humans, suggesting that RORα and the TL1A-DR3 circuit could be therapeutically targeted in atopic dermatitis."xsd:string |
| http://purl.uniprot.org/citations/29500225 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciimmunol.aao6923"xsd:string |
| http://purl.uniprot.org/citations/29500225 | http://purl.uniprot.org/core/author | "Siegel R.M."xsd:string |
| http://purl.uniprot.org/citations/29500225 | http://purl.uniprot.org/core/author | "Wang E.C."xsd:string |
| http://purl.uniprot.org/citations/29500225 | http://purl.uniprot.org/core/author | "Malhotra N."xsd:string |
| http://purl.uniprot.org/citations/29500225 | http://purl.uniprot.org/core/author | "Chambon P."xsd:string |
| http://purl.uniprot.org/citations/29500225 | http://purl.uniprot.org/core/author | "Geha R.S."xsd:string |
| http://purl.uniprot.org/citations/29500225 | http://purl.uniprot.org/core/author | "Barreiro O."xsd:string |
| http://purl.uniprot.org/citations/29500225 | http://purl.uniprot.org/core/author | "von Andrian U.H."xsd:string |
| http://purl.uniprot.org/citations/29500225 | http://purl.uniprot.org/core/author | "Meylan F."xsd:string |
| http://purl.uniprot.org/citations/29500225 | http://purl.uniprot.org/core/author | "Kam C."xsd:string |
| http://purl.uniprot.org/citations/29500225 | http://purl.uniprot.org/core/author | "Jadhav U."xsd:string |
| http://purl.uniprot.org/citations/29500225 | http://purl.uniprot.org/core/author | "Shivdasani R."xsd:string |
| http://purl.uniprot.org/citations/29500225 | http://purl.uniprot.org/core/author | "Leyva-Castillo J.M."xsd:string |
| http://purl.uniprot.org/citations/29500225 | http://purl.uniprot.org/core/author | "O'Neill N.K."xsd:string |
| http://purl.uniprot.org/citations/29500225 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29500225 | http://purl.uniprot.org/core/name | "Sci Immunol"xsd:string |
| http://purl.uniprot.org/citations/29500225 | http://purl.uniprot.org/core/pages | "eaao6923"xsd:string |
| http://purl.uniprot.org/citations/29500225 | http://purl.uniprot.org/core/title | "RORalpha-expressing T regulatory cells restrain allergic skin inflammation."xsd:string |
| http://purl.uniprot.org/citations/29500225 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/29500225 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29500225 |
| http://purl.uniprot.org/citations/29500225 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29500225 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGZ6-mappedCitation-29500225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29500225 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DG53-mappedCitation-29500225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29500225 |