| http://purl.uniprot.org/citations/29500416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29500416 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic myelogenous leukemia (CML) caused by hematopoietic stem cells expressing the Bcr-Abl fusion gene may be controlled by Bcr-Abl tyrosine kinase inhibitors (TKIs). However, CML-initiating cells are resistant to TKIs and may persist as minimal residual disease. We demonstrate that mice deficient in Sipa1, which encodes Rap1 GTPase-activating protein, rarely develop CML upon transfer of primary hematopoietic progenitor cells (HPCs) expressing Bcr-Abl, which cause lethal CML disease in wild-type mice. Resistance requires both T cells and nonhematopoietic cells. Sipa1-/- mesenchymal stroma cells (MSCs) show enhanced activation and directed migration to Bcr-Abl+ cells in tumor tissue and preferentially produce Cxcl9, which in turn recruits Sipa1-/- memory T cells that have markedly augmented chemotactic activity. Thus, Sipa1 deficiency uncovers a host immune mechanism potentially capable of eradicating Bcr-Abl+ HPCs via coordinated interplay between MSCs and immune T cells, which may provide a clue for radical control of human CML."xsd:string |
| http://purl.uniprot.org/citations/29500416 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-03307-8"xsd:string |
| http://purl.uniprot.org/citations/29500416 | http://purl.uniprot.org/core/author | "Tanaka H."xsd:string |
| http://purl.uniprot.org/citations/29500416 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/29500416 | http://purl.uniprot.org/core/author | "Minato N."xsd:string |
| http://purl.uniprot.org/citations/29500416 | http://purl.uniprot.org/core/author | "Ikeda S."xsd:string |
| http://purl.uniprot.org/citations/29500416 | http://purl.uniprot.org/core/author | "Yamamoto R."xsd:string |
| http://purl.uniprot.org/citations/29500416 | http://purl.uniprot.org/core/author | "Sumida K."xsd:string |
| http://purl.uniprot.org/citations/29500416 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29500416 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/29500416 | http://purl.uniprot.org/core/pages | "914"xsd:string |
| http://purl.uniprot.org/citations/29500416 | http://purl.uniprot.org/core/title | "Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells."xsd:string |
| http://purl.uniprot.org/citations/29500416 | http://purl.uniprot.org/core/volume | "9"xsd:string |
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