| http://purl.uniprot.org/citations/29507344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29507344 | http://www.w3.org/2000/01/rdf-schema#comment | "The cytokines CLCF1 and CNTF are ligands for the CNTF receptor and the apolipoprotein E (ApoE) receptor sortilin. Both share structural similarities with the N-terminal domain of ApoE, known to bind CNTF. We therefore evaluated whether ApoE or ApoE-containing lipoproteins interact with CLCF1 and regulate its activity. We observed that CLCF1 forms complexes with the three major isoforms of ApoE in co-immunoprecipitation and proximity assays. FPLC analysis of mouse and human sera mixed with CLCF1 revealed that CLCF1 co-purifies with plasma lipoproteins. Studies with sera from ApoE-/- mice indicate that ApoE is not required for CLCF1-lipoprotein interactions. VLDL- and LDL-CLCF1 binding was confirmed using proximity and ligand blots assays. CLCF1-induced STAT3 phosphorylation was significantly reduced when the cytokine was complexed with VLDL. Physiological relevance of our findings was asserted in a mouse model of oxygen-induced retinopathy, where the beneficial anti-angiogenic properties of CLCF1 were abrogated when co-administrated with VLDL, indicating, that CLCF1 binds purified lipoproteins or lipoproteins in physiological fluids such as serum and behave as a "lipocytokine". Albeit it is clear that lipoproteins modulate CLCF1 activity, it remains to be determined whether lipoprotein binding directly contributes to its neurotrophic function and its roles in metabolic regulation."xsd:string |
| http://purl.uniprot.org/citations/29507344 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-018-22400-y"xsd:string |
| http://purl.uniprot.org/citations/29507344 | http://purl.uniprot.org/core/author | "Martel C."xsd:string |
| http://purl.uniprot.org/citations/29507344 | http://purl.uniprot.org/core/author | "Sharma M."xsd:string |
| http://purl.uniprot.org/citations/29507344 | http://purl.uniprot.org/core/author | "Mayer G."xsd:string |
| http://purl.uniprot.org/citations/29507344 | http://purl.uniprot.org/core/author | "Bosse R."xsd:string |
| http://purl.uniprot.org/citations/29507344 | http://purl.uniprot.org/core/author | "Tormo A."xsd:string |
| http://purl.uniprot.org/citations/29507344 | http://purl.uniprot.org/core/author | "Sapieha P."xsd:string |
| http://purl.uniprot.org/citations/29507344 | http://purl.uniprot.org/core/author | "Gauchat J.F."xsd:string |
| http://purl.uniprot.org/citations/29507344 | http://purl.uniprot.org/core/author | "Dejda A."xsd:string |
| http://purl.uniprot.org/citations/29507344 | http://purl.uniprot.org/core/author | "Meliani Y."xsd:string |
| http://purl.uniprot.org/citations/29507344 | http://purl.uniprot.org/core/author | "Pasquin S."xsd:string |
| http://purl.uniprot.org/citations/29507344 | http://purl.uniprot.org/core/author | "Chehboun S."xsd:string |
| http://purl.uniprot.org/citations/29507344 | http://purl.uniprot.org/core/author | "Savin V."xsd:string |
| http://purl.uniprot.org/citations/29507344 | http://purl.uniprot.org/core/author | "Warner G.J."xsd:string |
| http://purl.uniprot.org/citations/29507344 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29507344 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/29507344 | http://purl.uniprot.org/core/pages | "3990"xsd:string |
| http://purl.uniprot.org/citations/29507344 | http://purl.uniprot.org/core/title | "Effect of human very low-density lipoproteins on cardiotrophin-like cytokine factor 1 (CLCF1) activity."xsd:string |
| http://purl.uniprot.org/citations/29507344 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/29507344 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29507344 |
| http://purl.uniprot.org/citations/29507344 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29507344 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GX15-mappedCitation-29507344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29507344 |
| http://purl.uniprot.org/uniprot/#_A0A494BA42-mappedCitation-29507344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29507344 |