| http://purl.uniprot.org/citations/29514919 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29514919 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29514919 | http://www.w3.org/2000/01/rdf-schema#comment | "Cholesterol, which is endocytosed to the late endosome (LE)/lysosome, is delivered to other organelles through vesicular and nonvesicular transport mechanisms. In this study, we discuss a novel mechanism of cholesterol transport from recycling endosomes (REs) to the trans-Golgi network (TGN) through RELCH/KIAA1468, which is newly identified in this study as a Rab11-GTP- and OSBP-binding protein. After treating cells with 25-hydroxycholesterol to induce OSBP relocation from the cytoplasm to the TGN, REs accumulated around the TGN area, but this accumulation was diminished in RELCH- or OSBP-depleted cells. Cholesterol content in the TGN was decreased in Rab11-, RELCH-, and OSBP-depleted cells and increased in the LE/lysosome. According to in vitro reconstitution experiments, RELCH tethers Rab11-bound RE-like and OSBP-bound TGN-like liposomes and promotes OSBP-dependent cholesterol transfer from RE-like to TGN-like liposomes. These data suggest that RELCH promotes nonvesicular cholesterol transport from REs to the TGN through membrane tethering."xsd:string |
| http://purl.uniprot.org/citations/29514919 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201709123"xsd:string |
| http://purl.uniprot.org/citations/29514919 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201709123"xsd:string |
| http://purl.uniprot.org/citations/29514919 | http://purl.uniprot.org/core/author | "Maeda T."xsd:string |
| http://purl.uniprot.org/citations/29514919 | http://purl.uniprot.org/core/author | "Maeda T."xsd:string |
| http://purl.uniprot.org/citations/29514919 | http://purl.uniprot.org/core/author | "Miyata H."xsd:string |
| http://purl.uniprot.org/citations/29514919 | http://purl.uniprot.org/core/author | "Miyata H."xsd:string |
| http://purl.uniprot.org/citations/29514919 | http://purl.uniprot.org/core/author | "Harada A."xsd:string |
| http://purl.uniprot.org/citations/29514919 | http://purl.uniprot.org/core/author | "Harada A."xsd:string |
| http://purl.uniprot.org/citations/29514919 | http://purl.uniprot.org/core/author | "Miyoshi E."xsd:string |
| http://purl.uniprot.org/citations/29514919 | http://purl.uniprot.org/core/author | "Miyoshi E."xsd:string |
| http://purl.uniprot.org/citations/29514919 | http://purl.uniprot.org/core/author | "Sobajima T."xsd:string |
| http://purl.uniprot.org/citations/29514919 | http://purl.uniprot.org/core/author | "Sobajima T."xsd:string |
| http://purl.uniprot.org/citations/29514919 | http://purl.uniprot.org/core/author | "Yoshimura S.I."xsd:string |
| http://purl.uniprot.org/citations/29514919 | http://purl.uniprot.org/core/author | "Yoshimura S.I."xsd:string |
| http://purl.uniprot.org/citations/29514919 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29514919 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29514919 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/29514919 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/29514919 | http://purl.uniprot.org/core/pages | "1777-1796"xsd:string |
| http://purl.uniprot.org/citations/29514919 | http://purl.uniprot.org/core/pages | "1777-1796"xsd:string |
| http://purl.uniprot.org/citations/29514919 | http://purl.uniprot.org/core/title | "The Rab11-binding protein RELCH/KIAA1468 controls intracellular cholesterol distribution."xsd:string |
| http://purl.uniprot.org/citations/29514919 | http://purl.uniprot.org/core/title | "The Rab11-binding protein RELCH/KIAA1468 controls intracellular cholesterol distribution."xsd:string |