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| http://purl.uniprot.org/citations/29515365 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in the transcription factor methyl-CpG-binding protein 2 (MeCP2) cause the neurodevelopmental disorder Rett syndrome (RTT). Besides many other neurological problems, RTT patients show irregular breathing with recurrent apneas or breath-holdings. MeCP2-deficient mice, which recapitulate this breathing phenotype, show a dysregulated, persistent expression of G-protein-coupled serotonin receptor 5-ht5b (Htr5b) in the brainstem. To investigate whether the persistence of 5-ht5b expression is contributing to the respiratory phenotype, we crossbred MeCP2-deficient mice with 5-ht5b-deficient mice to generate double knockout mice (Mecp2-/y ;Htr5b-/-). To compare respiration between wild type (WT), Mecp2-/y and Mecp2-/y ;Htr5b-/- mice, we used unrestrained whole-body plethysmography. While the breathing of MeCP2-deficient male mice (Mecp2-/y ) at postnatal day 40 is characterized by a slow breathing rate and the occurrence of prolonged respiratory pauses, we found that in MeCP2-deficient mice, which also lacked the 5-ht5b receptor, the breathing rate and the number of pauses were indistinguishable from WT mice. To test for a potential mechanism, we also analyzed if the known coupling of 5-ht5b receptors to Gi proteins is altering second messenger signaling. Tissue cAMP levels in the medulla of Mecp2-/y mice were decreased as compared to WT mice. In contrast, cAMP levels in Mecp2-/y ;Htr5b-/- mice were indistinguishable from WT mice. Taken together, our data points towards a role of 5-ht5b receptors within the complex breathing phenotype of MeCP2-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/29515365 | http://purl.org/dc/terms/identifier | "doi:10.3389/fnmol.2018.00028"xsd:string |
| http://purl.uniprot.org/citations/29515365 | http://purl.uniprot.org/core/author | "Niebert M."xsd:string |
| http://purl.uniprot.org/citations/29515365 | http://purl.uniprot.org/core/author | "Manzke T."xsd:string |
| http://purl.uniprot.org/citations/29515365 | http://purl.uniprot.org/core/author | "Vogelgesang S."xsd:string |
| http://purl.uniprot.org/citations/29515365 | http://purl.uniprot.org/core/author | "Bischoff A.M."xsd:string |
| http://purl.uniprot.org/citations/29515365 | http://purl.uniprot.org/core/author | "Hulsmann S."xsd:string |
| http://purl.uniprot.org/citations/29515365 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29515365 | http://purl.uniprot.org/core/name | "Front Mol Neurosci"xsd:string |
| http://purl.uniprot.org/citations/29515365 | http://purl.uniprot.org/core/pages | "28"xsd:string |
| http://purl.uniprot.org/citations/29515365 | http://purl.uniprot.org/core/title | "Persistent Expression of Serotonin Receptor 5b Alters Breathing Behavior in Male MeCP2 Knockout Mice."xsd:string |
| http://purl.uniprot.org/citations/29515365 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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