| http://purl.uniprot.org/citations/29515371 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29515371 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29515371 | http://www.w3.org/2000/01/rdf-schema#comment | "Retinal degeneration protein 3 (RD3) is crucial for photoreceptor cell survival and linked to Leber Congenital Amaurosis type 12 (LCA12), a hereditary retinal disease in humans. RD3 inhibits photoreceptor guanylate cyclases GC-E and GC-F and is involved in transport of GCs from the inner to the outer segments. Otherwise, its role in photoreceptor physiology is poorly understood. Here, we describe a new function of RD3. Purified RD3 evoked an increase in guanylate kinase activity, an enzyme that is involved in the nucleotide cycle in photoreceptors. We demonstrate a direct interaction between guanylate kinase and RD3 using back-scattering interferometry and show by immunohistochemistry of mouse retina sections that RD3 and guanylate kinase co-localize in photoreceptor inner segments and to a lesser extent in the outer plexiform layer. Our findings point toward a more complex function of RD3 in photoreceptors. The RD3 - guanylate kinase interaction may also play a role in other cellular systems, while the GC - RD3 interaction is exclusive to photoreceptors."xsd:string |
| http://purl.uniprot.org/citations/29515371 | http://purl.org/dc/terms/identifier | "doi:10.3389/fnmol.2018.00052"xsd:string |
| http://purl.uniprot.org/citations/29515371 | http://purl.org/dc/terms/identifier | "doi:10.3389/fnmol.2018.00052"xsd:string |
| http://purl.uniprot.org/citations/29515371 | http://purl.uniprot.org/core/author | "Janssen-Bienhold U."xsd:string |
| http://purl.uniprot.org/citations/29515371 | http://purl.uniprot.org/core/author | "Janssen-Bienhold U."xsd:string |
| http://purl.uniprot.org/citations/29515371 | http://purl.uniprot.org/core/author | "Koch K.W."xsd:string |
| http://purl.uniprot.org/citations/29515371 | http://purl.uniprot.org/core/author | "Koch K.W."xsd:string |
| http://purl.uniprot.org/citations/29515371 | http://purl.uniprot.org/core/author | "Wimberg H."xsd:string |
| http://purl.uniprot.org/citations/29515371 | http://purl.uniprot.org/core/author | "Wimberg H."xsd:string |
| http://purl.uniprot.org/citations/29515371 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29515371 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29515371 | http://purl.uniprot.org/core/name | "Front. Mol. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/29515371 | http://purl.uniprot.org/core/name | "Front. Mol. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/29515371 | http://purl.uniprot.org/core/pages | "52"xsd:string |
| http://purl.uniprot.org/citations/29515371 | http://purl.uniprot.org/core/pages | "52"xsd:string |
| http://purl.uniprot.org/citations/29515371 | http://purl.uniprot.org/core/title | "Control of the Nucleotide Cycle in Photoreceptor Cell Extracts by Retinal Degeneration Protein 3."xsd:string |
| http://purl.uniprot.org/citations/29515371 | http://purl.uniprot.org/core/title | "Control of the Nucleotide Cycle in Photoreceptor Cell Extracts by Retinal Degeneration Protein 3."xsd:string |
| http://purl.uniprot.org/citations/29515371 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/29515371 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/29515371 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29515371 |
| http://purl.uniprot.org/citations/29515371 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29515371 |
| http://purl.uniprot.org/citations/29515371 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29515371 |
| http://purl.uniprot.org/citations/29515371 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29515371 |