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| http://purl.uniprot.org/citations/29519915 | http://www.w3.org/2000/01/rdf-schema#comment | "The RNA exosome complex processes and degrades a wide range of transcripts, including ribosomal RNAs (rRNAs). We used cryo-electron microscopy to visualize the yeast nuclear exosome holocomplex captured on a precursor large ribosomal subunit (pre-60S) during 7S-to-5.8S rRNA processing. The cofactors of the nuclear exosome are sandwiched between the ribonuclease core complex (Exo-10) and the remodeled "foot" structure of the pre-60S particle, which harbors the 5.8S rRNA precursor. The exosome-associated helicase Mtr4 recognizes the preribosomal substrate by docking to specific sites on the 25S rRNA, captures the 3' extension of the 5.8S rRNA, and channels it toward Exo-10. The structure elucidates how the exosome forms a structural and functional unit together with its massive pre-60S substrate to process rRNA during ribosome maturation."xsd:string |
| http://purl.uniprot.org/citations/29519915 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aar5428"xsd:string |
| http://purl.uniprot.org/citations/29519915 | http://purl.uniprot.org/core/author | "Conti E."xsd:string |
| http://purl.uniprot.org/citations/29519915 | http://purl.uniprot.org/core/author | "Schuller J.M."xsd:string |
| http://purl.uniprot.org/citations/29519915 | http://purl.uniprot.org/core/author | "Hurt E."xsd:string |
| http://purl.uniprot.org/citations/29519915 | http://purl.uniprot.org/core/author | "Falk S."xsd:string |
| http://purl.uniprot.org/citations/29519915 | http://purl.uniprot.org/core/author | "Fromm L."xsd:string |
| http://purl.uniprot.org/citations/29519915 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29519915 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/29519915 | http://purl.uniprot.org/core/pages | "219-222"xsd:string |
| http://purl.uniprot.org/citations/29519915 | http://purl.uniprot.org/core/title | "Structure of the nuclear exosome captured on a maturing preribosome."xsd:string |
| http://purl.uniprot.org/citations/29519915 | http://purl.uniprot.org/core/volume | "360"xsd:string |
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