| http://purl.uniprot.org/citations/29523656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29523656 | http://www.w3.org/2000/01/rdf-schema#comment | "By their interaction with IgG immune complexes, FcγR and complement link innate and adaptive immunity, showing functional redundancy. In complement-deficient mice, IgG downstream effector functions are often impaired, as well as adaptive immunity. Based on a variety of model systems using FcγR-knockout mice, it has been concluded that FcγRs are also key regulators of innate and adaptive immunity; however, several of the model systems underpinning these conclusions suffer from flawed experimental design. To address this issue, we generated a novel mouse model deficient for all FcγRs (FcγRI/II/III/IV-/- mice). These mice displayed normal development and lymphoid and myeloid ontogeny. Although IgG effector pathways were impaired, adaptive immune responses to a variety of challenges, including bacterial infection and IgG immune complexes, were not. Like FcγRIIb-deficient mice, FcγRI/II/III/IV-/- mice developed higher Ab titers but no autoantibodies. These observations indicate a redundant role for activating FcγRs in the modulation of the adaptive immune response in vivo. We conclude that FcγRs are downstream IgG effector molecules with a restricted role in the ontogeny and maintenance of the immune system, as well as the regulation of adaptive immunity."xsd:string |
| http://purl.uniprot.org/citations/29523656 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1700429"xsd:string |
| http://purl.uniprot.org/citations/29523656 | http://purl.uniprot.org/core/author | "Lin Q."xsd:string |
| http://purl.uniprot.org/citations/29523656 | http://purl.uniprot.org/core/author | "Hirose S."xsd:string |
| http://purl.uniprot.org/citations/29523656 | http://purl.uniprot.org/core/author | "Camps M."xsd:string |
| http://purl.uniprot.org/citations/29523656 | http://purl.uniprot.org/core/author | "van Kooten C."xsd:string |
| http://purl.uniprot.org/citations/29523656 | http://purl.uniprot.org/core/author | "Ossendorp F."xsd:string |
| http://purl.uniprot.org/citations/29523656 | http://purl.uniprot.org/core/author | "Coward C."xsd:string |
| http://purl.uniprot.org/citations/29523656 | http://purl.uniprot.org/core/author | "Breukel C."xsd:string |
| http://purl.uniprot.org/citations/29523656 | http://purl.uniprot.org/core/author | "Daxinger L."xsd:string |
| http://purl.uniprot.org/citations/29523656 | http://purl.uniprot.org/core/author | "Verbeek J.S."xsd:string |
| http://purl.uniprot.org/citations/29523656 | http://purl.uniprot.org/core/author | "Holmdahl R."xsd:string |
| http://purl.uniprot.org/citations/29523656 | http://purl.uniprot.org/core/author | "Mastroeni P."xsd:string |
| http://purl.uniprot.org/citations/29523656 | http://purl.uniprot.org/core/author | "Brouwers C."xsd:string |
| http://purl.uniprot.org/citations/29523656 | http://purl.uniprot.org/core/author | "van Harmelen V."xsd:string |
| http://purl.uniprot.org/citations/29523656 | http://purl.uniprot.org/core/author | "van Hall T."xsd:string |
| http://purl.uniprot.org/citations/29523656 | http://purl.uniprot.org/core/author | "Nandakumar K.S."xsd:string |
| http://purl.uniprot.org/citations/29523656 | http://purl.uniprot.org/core/author | "Fransen M.F."xsd:string |
| http://purl.uniprot.org/citations/29523656 | http://purl.uniprot.org/core/author | "van der Kaa J."xsd:string |
| http://purl.uniprot.org/citations/29523656 | http://purl.uniprot.org/core/author | "Salvatori D."xsd:string |
| http://purl.uniprot.org/citations/29523656 | http://purl.uniprot.org/core/author | "Linssen M.M."xsd:string |
| http://purl.uniprot.org/citations/29523656 | http://purl.uniprot.org/core/author | "Kleinovink J.W."xsd:string |
| http://purl.uniprot.org/citations/29523656 | http://purl.uniprot.org/core/author | "van Beek L."xsd:string |
| http://purl.uniprot.org/citations/29523656 | http://purl.uniprot.org/core/author | "Vonk K.K."xsd:string |