| http://purl.uniprot.org/citations/29523893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29523893 | http://www.w3.org/2000/01/rdf-schema#comment | "Apical-basal polarity is an important characteristic of epithelia and Drosophila neural stem cells. The conserved Par complex, which consists of the atypical protein kinase C and the scaffold proteins Baz and Par6, is a key player in the establishment of apical-basal cell polarity. Membrane recruitment of Baz has been reported to be accomplished by several mechanisms, which might function in redundancy, to ensure the correct localization of the complex. However, none of the described interactions was sufficient to displace the protein from the apical junctions. Here, we dissected the role of the oligomerization domain and the lipid-binding motif of Baz in vivo in the Drosophila embryo. We found that these domains function in redundancy to ensure the apical junctional localization of Baz: inactivation of only one domain is not sufficient to disrupt the function of Baz during apical-basal polarization of epithelial cells and neural stem cells. In contrast, mutation of both domains results in a strongly impaired protein stability and a phenotype characterized by embryonic lethality and an impaired apical-basal polarity in the embryonic epithelium and neural stem cells, resembling a baz-loss of function allele. Strikingly, the binding of Baz to the transmembrane proteins E-Cadherin, Echinoid, and Starry Night was not affected in this mutant protein. Our findings reveal a redundant function of the oligomerization and the lipid-binding domain, which is required for protein stability, correct subcellular localization, and apical-basal cell polarization."xsd:string |
| http://purl.uniprot.org/citations/29523893 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00018-018-2792-1"xsd:string |
| http://purl.uniprot.org/citations/29523893 | http://purl.uniprot.org/core/author | "Krahn M.P."xsd:string |
| http://purl.uniprot.org/citations/29523893 | http://purl.uniprot.org/core/author | "Kullmann L."xsd:string |
| http://purl.uniprot.org/citations/29523893 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29523893 | http://purl.uniprot.org/core/name | "Cell Mol Life Sci"xsd:string |
| http://purl.uniprot.org/citations/29523893 | http://purl.uniprot.org/core/pages | "3269-3282"xsd:string |
| http://purl.uniprot.org/citations/29523893 | http://purl.uniprot.org/core/title | "Redundant regulation of localization and protein stability of DmPar3."xsd:string |
| http://purl.uniprot.org/citations/29523893 | http://purl.uniprot.org/core/volume | "75"xsd:string |
| http://purl.uniprot.org/citations/29523893 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29523893 |
| http://purl.uniprot.org/citations/29523893 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29523893 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFQ6-mappedCitation-29523893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29523893 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KG15-mappedCitation-29523893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29523893 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHS3-mappedCitation-29523893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29523893 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEQ8-mappedCitation-29523893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29523893 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KER2-mappedCitation-29523893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29523893 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEV2-mappedCitation-29523893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29523893 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6X2-mappedCitation-29523893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29523893 |
| http://purl.uniprot.org/uniprot/#_E1JH30-mappedCitation-29523893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29523893 |
| http://purl.uniprot.org/uniprot/#_A0A0B4JD78-mappedCitation-29523893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29523893 |
| http://purl.uniprot.org/uniprot/#_A0A0B4JD26-mappedCitation-29523893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29523893 |
| http://purl.uniprot.org/uniprot/#_A0A0B4JD63-mappedCitation-29523893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29523893 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LG27-mappedCitation-29523893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29523893 |
| http://purl.uniprot.org/uniprot/#_A4V1F9-mappedCitation-29523893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29523893 |