| http://purl.uniprot.org/citations/29525521 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29525521 | http://www.w3.org/2000/01/rdf-schema#comment | "Although interferon-induced proteins with tetratricopeptide repeats (IFIT proteins) inhibit infection of many viruses by recognizing their RNA, the regulatory mechanisms involved remain unclear. Here we report a crystal structure of cap 0 (m7GpppN) RNA bound to human IFIT1 in complex with the C-terminal domain of human IFIT3. Structural, biochemical, and genetic studies suggest that IFIT3 binding to IFIT1 has dual regulatory functions: (1) extending the half-life of IFIT1 and thereby increasing its steady-state amounts in cells; and (2) allosterically regulating the IFIT1 RNA-binding channel, thereby enhancing the specificity of recognition for cap 0 but not cap 1 (m7GpppNm) or 5'-ppp RNA. Mouse Ifit3 lacks this key C-terminal domain and does not bind mouse Ifit1. The IFIT3 interaction with IFIT1 is important for restricting infection of viruses lacking 2'-O methylation in their RNA cap structures. Our experiments establish differences in the regulation of IFIT1 orthologs and define targets for modulation of human IFIT protein activity."xsd:string |
| http://purl.uniprot.org/citations/29525521 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2018.01.014"xsd:string |
| http://purl.uniprot.org/citations/29525521 | http://purl.uniprot.org/core/author | "Gross M.L."xsd:string |
| http://purl.uniprot.org/citations/29525521 | http://purl.uniprot.org/core/author | "Xu W."xsd:string |
| http://purl.uniprot.org/citations/29525521 | http://purl.uniprot.org/core/author | "Zhang R."xsd:string |
| http://purl.uniprot.org/citations/29525521 | http://purl.uniprot.org/core/author | "White J.P."xsd:string |
| http://purl.uniprot.org/citations/29525521 | http://purl.uniprot.org/core/author | "Diamond M.S."xsd:string |
| http://purl.uniprot.org/citations/29525521 | http://purl.uniprot.org/core/author | "Amarasinghe G.K."xsd:string |
| http://purl.uniprot.org/citations/29525521 | http://purl.uniprot.org/core/author | "Leung D.W."xsd:string |
| http://purl.uniprot.org/citations/29525521 | http://purl.uniprot.org/core/author | "Johnson B."xsd:string |
| http://purl.uniprot.org/citations/29525521 | http://purl.uniprot.org/core/author | "Shi P.Y."xsd:string |
| http://purl.uniprot.org/citations/29525521 | http://purl.uniprot.org/core/author | "Shan C."xsd:string |
| http://purl.uniprot.org/citations/29525521 | http://purl.uniprot.org/core/author | "VanBlargan L.A."xsd:string |
| http://purl.uniprot.org/citations/29525521 | http://purl.uniprot.org/core/author | "Adhikari J."xsd:string |
| http://purl.uniprot.org/citations/29525521 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29525521 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/29525521 | http://purl.uniprot.org/core/pages | "487-499.e5"xsd:string |
| http://purl.uniprot.org/citations/29525521 | http://purl.uniprot.org/core/title | "Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability."xsd:string |
| http://purl.uniprot.org/citations/29525521 | http://purl.uniprot.org/core/volume | "48"xsd:string |
| http://purl.uniprot.org/citations/29525521 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29525521 |
| http://purl.uniprot.org/citations/29525521 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29525521 |
| http://purl.uniprot.org/uniprot/#_P09914-mappedCitation-29525521 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29525521 |
| http://purl.uniprot.org/uniprot/#_O14879-mappedCitation-29525521 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29525521 |
| http://purl.uniprot.org/uniprot/O14879 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29525521 |