| http://purl.uniprot.org/citations/29526696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29526696 | http://www.w3.org/2000/01/rdf-schema#comment | "The lineage-specific transcription factor (TF) MEF2C is often deregulated in leukemia. However, strategies to target this TF have yet to be identified. Here, we used a domain-focused CRISPR screen to reveal an essential role for LKB1 and its Salt-Inducible Kinase effectors (SIK3, in a partially redundant manner with SIK2) to maintain MEF2C function in acute myeloid leukemia (AML). A key phosphorylation substrate of SIK3 in this context is HDAC4, a repressive cofactor of MEF2C. Consequently, targeting of LKB1 or SIK3 diminishes histone acetylation at MEF2C-bound enhancers and deprives leukemia cells of the output of this essential TF. We also found that MEF2C-dependent leukemias are sensitive to on-target chemical inhibition of SIK activity. This study reveals a chemical strategy to block MEF2C function in AML, highlighting how an oncogenic TF can be disabled by targeting of upstream kinases."xsd:string |
| http://purl.uniprot.org/citations/29526696 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2018.02.011"xsd:string |
| http://purl.uniprot.org/citations/29526696 | http://purl.uniprot.org/core/author | "Shi J."xsd:string |
| http://purl.uniprot.org/citations/29526696 | http://purl.uniprot.org/core/author | "Lu B."xsd:string |
| http://purl.uniprot.org/citations/29526696 | http://purl.uniprot.org/core/author | "Huang Y.H."xsd:string |
| http://purl.uniprot.org/citations/29526696 | http://purl.uniprot.org/core/author | "Wu X.S."xsd:string |
| http://purl.uniprot.org/citations/29526696 | http://purl.uniprot.org/core/author | "Vakoc C.R."xsd:string |
| http://purl.uniprot.org/citations/29526696 | http://purl.uniprot.org/core/author | "Somerville T.D.D."xsd:string |
| http://purl.uniprot.org/citations/29526696 | http://purl.uniprot.org/core/author | "El Demerdash O."xsd:string |
| http://purl.uniprot.org/citations/29526696 | http://purl.uniprot.org/core/author | "Tarumoto Y."xsd:string |
| http://purl.uniprot.org/citations/29526696 | http://purl.uniprot.org/core/author | "Milazzo J.P."xsd:string |
| http://purl.uniprot.org/citations/29526696 | http://purl.uniprot.org/core/author | "Klingbeil O."xsd:string |
| http://purl.uniprot.org/citations/29526696 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29526696 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/29526696 | http://purl.uniprot.org/core/pages | "1017-1027.e6"xsd:string |
| http://purl.uniprot.org/citations/29526696 | http://purl.uniprot.org/core/title | "LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia."xsd:string |
| http://purl.uniprot.org/citations/29526696 | http://purl.uniprot.org/core/volume | "69"xsd:string |
| http://purl.uniprot.org/citations/29526696 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29526696 |
| http://purl.uniprot.org/citations/29526696 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29526696 |
| http://purl.uniprot.org/uniprot/#_A0A0D9SFD0-mappedCitation-29526696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29526696 |
| http://purl.uniprot.org/uniprot/#_D4P556-mappedCitation-29526696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29526696 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4C7-mappedCitation-29526696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29526696 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4D1-mappedCitation-29526696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29526696 |
| http://purl.uniprot.org/uniprot/#_A6YR18-mappedCitation-29526696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29526696 |