| http://purl.uniprot.org/citations/29531227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29531227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29531227 | http://www.w3.org/2000/01/rdf-schema#comment | "Human leukocyte antigen (HLA)-I molecules generally bind short peptides (8-10 amino acids), although extended HLA-I restricted peptides (>10 amino acids) can be presented to T cells. However, the function of such extended HLA-I epitopes in tumour immunity, and how they would be recognised by T-cell receptors (TCR) remains unclear. Here we show that the structures of two distinct TCRs (TRAV4+TRAJ21+-TRBV28+TRBJ2-3+ and TRAV4 + TRAJ8+-TRBV9+TRBJ2-1+), originating from a polyclonal T-cell repertoire, bind to HLA-B*07:02, presenting a 13-amino-acid-long tumour-associated peptide, NY-ESO-160-72. Comparison of the structures reveals that the two TCRs differentially binds NY-ESO-160-72-HLA-B*07:02 complex, and induces differing extent of conformational change of the NY-ESO-160-72 epitope. Accordingly, polyclonal TCR usage towards an extended HLA-I restricted tumour epitope translates to differing TCR recognition modes, whereby extensive flexibility at the TCR-pHLA-I interface engenders recognition."xsd:string |
| http://purl.uniprot.org/citations/29531227 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-03321-w"xsd:string |
| http://purl.uniprot.org/citations/29531227 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-03321-w"xsd:string |
| http://purl.uniprot.org/citations/29531227 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/29531227 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/29531227 | http://purl.uniprot.org/core/author | "Rossjohn J."xsd:string |
| http://purl.uniprot.org/citations/29531227 | http://purl.uniprot.org/core/author | "Rossjohn J."xsd:string |
| http://purl.uniprot.org/citations/29531227 | http://purl.uniprot.org/core/author | "Gras S."xsd:string |
| http://purl.uniprot.org/citations/29531227 | http://purl.uniprot.org/core/author | "Gras S."xsd:string |
| http://purl.uniprot.org/citations/29531227 | http://purl.uniprot.org/core/author | "Kjer-Nielsen L."xsd:string |
| http://purl.uniprot.org/citations/29531227 | http://purl.uniprot.org/core/author | "Kjer-Nielsen L."xsd:string |
| http://purl.uniprot.org/citations/29531227 | http://purl.uniprot.org/core/author | "McCluskey J."xsd:string |
| http://purl.uniprot.org/citations/29531227 | http://purl.uniprot.org/core/author | "McCluskey J."xsd:string |
| http://purl.uniprot.org/citations/29531227 | http://purl.uniprot.org/core/author | "Cebon J."xsd:string |
| http://purl.uniprot.org/citations/29531227 | http://purl.uniprot.org/core/author | "Cebon J."xsd:string |
| http://purl.uniprot.org/citations/29531227 | http://purl.uniprot.org/core/author | "Beringer D.X."xsd:string |
| http://purl.uniprot.org/citations/29531227 | http://purl.uniprot.org/core/author | "Beringer D.X."xsd:string |
| http://purl.uniprot.org/citations/29531227 | http://purl.uniprot.org/core/author | "Gully B.S."xsd:string |
| http://purl.uniprot.org/citations/29531227 | http://purl.uniprot.org/core/author | "Gully B.S."xsd:string |
| http://purl.uniprot.org/citations/29531227 | http://purl.uniprot.org/core/author | "Chan K.F."xsd:string |
| http://purl.uniprot.org/citations/29531227 | http://purl.uniprot.org/core/author | "Chan K.F."xsd:string |
| http://purl.uniprot.org/citations/29531227 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29531227 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |