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http://purl.uniprot.org/citations/29534305http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/29534305http://www.w3.org/2000/01/rdf-schema#comment"

Background and objectives

Gastric cancer (GC) has recently been categorized in molecular subtypes, which include Epstein-Barr (EBV)-positive and microsatellite instability (MSI) tumors. This distinction may provide prognostic information and identifies therapeutic targets. The aim of this study was to evaluate EBV, MSI, and PD-L1 immunoexpression in GC and its relationship with clinicopathological characteristics and patient's prognosis.

Methods

We evaluated 287 GC patients who underwent D2-gastrectomy through immunohistochemistry for DNA mismatch repair proteins and PD-L1, and in situ hybridization for EBV detection utilizing tissue microarray.

Results

EBV-positive and MSI were identified in 10.5% and 27% of the GCs, respectively. EBV positivity was associated to male gender (P = 0.032), proximal location (P < 0.001), undetermined Lauren type (P < 0.001), poorly differentiated histology (P = 0.043) and severe inflammatory infiltrate (P < 0.001). MSI-tumors were associated to older age (P = 0.002), subtotal gastrectomy (P = 0.004), pN0 (P = 0.024) and earlier TNM stage (P = 0.020). PD-L1-positive was seen in 8.8% of cases, with predominant expression in EBV-positive GC (P < 0.001). MSI was associated to better survival outcomes.

Conclusion

EBV-positive GCs had increased PD-L1 expression, while MSI GC had better survival outcome. EBV and MSI subgroups are distinct GC entities, their recognition is feasible by conventional techniques, and it may help individualize follow-up and guide adjuvant therapy."xsd:string
http://purl.uniprot.org/citations/29534305http://purl.org/dc/terms/identifier"doi:10.1002/jso.25022"xsd:string
http://purl.uniprot.org/citations/29534305http://purl.uniprot.org/core/author"Pereira M.A."xsd:string
http://purl.uniprot.org/citations/29534305http://purl.uniprot.org/core/author"Dias A.R."xsd:string
http://purl.uniprot.org/citations/29534305http://purl.uniprot.org/core/author"Alves V.A.F."xsd:string
http://purl.uniprot.org/citations/29534305http://purl.uniprot.org/core/author"de Mello E.S."xsd:string
http://purl.uniprot.org/citations/29534305http://purl.uniprot.org/core/author"Cecconello I."xsd:string
http://purl.uniprot.org/citations/29534305http://purl.uniprot.org/core/author"Ribeiro U. Jr."xsd:string
http://purl.uniprot.org/citations/29534305http://purl.uniprot.org/core/author"Faraj S.F."xsd:string
http://purl.uniprot.org/citations/29534305http://purl.uniprot.org/core/author"Ramos M.F.K.P."xsd:string
http://purl.uniprot.org/citations/29534305http://purl.uniprot.org/core/author"Yagi O.K."xsd:string
http://purl.uniprot.org/citations/29534305http://purl.uniprot.org/core/author"Zilberstein B."xsd:string
http://purl.uniprot.org/citations/29534305http://purl.uniprot.org/core/date"2018"xsd:gYear
http://purl.uniprot.org/citations/29534305http://purl.uniprot.org/core/name"J Surg Oncol"xsd:string
http://purl.uniprot.org/citations/29534305http://purl.uniprot.org/core/pages"829-839"xsd:string
http://purl.uniprot.org/citations/29534305http://purl.uniprot.org/core/title"Clinicopathological and prognostic features of Epstein-Barr virus infection, microsatellite instability, and PD-L1 expression in gastric cancer."xsd:string
http://purl.uniprot.org/citations/29534305http://purl.uniprot.org/core/volume"117"xsd:string
http://purl.uniprot.org/citations/29534305http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/29534305
http://purl.uniprot.org/citations/29534305http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/29534305
http://purl.uniprot.org/uniprot/#_Q0GN75-mappedCitation-29534305http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29534305
http://purl.uniprot.org/uniprot/#_Q9NZQ7-mappedCitation-29534305http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29534305
http://purl.uniprot.org/uniprot/Q0GN75http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/29534305
http://purl.uniprot.org/uniprot/Q9NZQ7http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/29534305