| http://purl.uniprot.org/citations/29538402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29538402 | http://www.w3.org/2000/01/rdf-schema#comment | "Amino acid signaling mediated by the activation of mechanistic target of rapamycin complex 1 (mTORC1) is fundamental to cell growth and metabolism. However, how cells negatively regulate amino acid signaling remains largely unknown. Here, we show that interaction between 4F2 heavy chain (4F2hc), a subunit of multiple amino acid transporters, and the multifunctional hub protein girders of actin filaments (Girdin) down-regulates mTORC1 activity. 4F2hc interacts with Girdin in mitogen-activated protein kinase (MAPK)- and amino acid signaling-dependent manners to translocate to the lysosome. The resultant decrease in cell surface 4F2hc leads to lowered cytoplasmic glutamine (Gln) and leucine (Leu) content, which down-regulates amino acid signaling. Consistently, Girdin depletion augments amino acid-induced mTORC1 activation and inhibits amino acid deprivation-induced autophagy. These findings uncovered the mechanism underlying negative regulation of amino acid signaling, which may play a role in tightly regulated cell growth and metabolism."xsd:string |
| http://purl.uniprot.org/citations/29538402 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pbio.2005090"xsd:string |
| http://purl.uniprot.org/citations/29538402 | http://purl.uniprot.org/core/author | "An J."xsd:string |
| http://purl.uniprot.org/citations/29538402 | http://purl.uniprot.org/core/author | "Takahashi M."xsd:string |
| http://purl.uniprot.org/citations/29538402 | http://purl.uniprot.org/core/author | "Shimomura Y."xsd:string |
| http://purl.uniprot.org/citations/29538402 | http://purl.uniprot.org/core/author | "Kanai Y."xsd:string |
| http://purl.uniprot.org/citations/29538402 | http://purl.uniprot.org/core/author | "Nagamori S."xsd:string |
| http://purl.uniprot.org/citations/29538402 | http://purl.uniprot.org/core/author | "Asai M."xsd:string |
| http://purl.uniprot.org/citations/29538402 | http://purl.uniprot.org/core/author | "Kitaura Y."xsd:string |
| http://purl.uniprot.org/citations/29538402 | http://purl.uniprot.org/core/author | "Weng L."xsd:string |
| http://purl.uniprot.org/citations/29538402 | http://purl.uniprot.org/core/author | "Asai N."xsd:string |
| http://purl.uniprot.org/citations/29538402 | http://purl.uniprot.org/core/author | "Enomoto A."xsd:string |
| http://purl.uniprot.org/citations/29538402 | http://purl.uniprot.org/core/author | "Takagishi M."xsd:string |
| http://purl.uniprot.org/citations/29538402 | http://purl.uniprot.org/core/author | "Masuko T."xsd:string |
| http://purl.uniprot.org/citations/29538402 | http://purl.uniprot.org/core/author | "Mii S."xsd:string |
| http://purl.uniprot.org/citations/29538402 | http://purl.uniprot.org/core/author | "Han Y.P."xsd:string |
| http://purl.uniprot.org/citations/29538402 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29538402 | http://purl.uniprot.org/core/name | "PLoS Biol"xsd:string |
| http://purl.uniprot.org/citations/29538402 | http://purl.uniprot.org/core/pages | "e2005090"xsd:string |
| http://purl.uniprot.org/citations/29538402 | http://purl.uniprot.org/core/title | "Negative regulation of amino acid signaling by MAPK-regulated 4F2hc/Girdin complex."xsd:string |
| http://purl.uniprot.org/citations/29538402 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/29538402 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29538402 |
| http://purl.uniprot.org/citations/29538402 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29538402 |
| http://purl.uniprot.org/uniprot/#_A0A6I8MX08-mappedCitation-29538402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29538402 |