| http://purl.uniprot.org/citations/29540318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29540318 | http://www.w3.org/2000/01/rdf-schema#comment | "Assembly of complex I of the mitochondrial respiratory chain (MRC) requires not only structural subunits for electron transport, but also assembly factors. In the nematode Caenorhabditis elegans, NUAF-1 and NUAF-3 are the only two assembly factors that have been characterized. In this study, we identify ACDH-12 as an assembly factor of the respiratory complex I. We demonstrate for the first time that a deficiency of ACDH-12 affects the formation and function of complex I. RNAi knockdown of acdh-12 also shortens lifespan and decreases fecundity. Although ACDH-12 has long been recognized as a very long-chain acyl-CoA dehydrogenase (VLCAD), the knockdown nematodes did not exhibit any change in body fat content. We suggested that in Caenorhabditis elegans, ACDH-12 is required for the assembly of the respiratory complex I, but may not be crucial to fatty acid oxidation. Interestingly, sequence analysis shows high homology between ACDH-12 and the human ACAD9, a protein that has initially been identified as a VLCAD, but later found to also be involved in the assembly of complex I in human."xsd:string |
| http://purl.uniprot.org/citations/29540318 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mito.2018.02.010"xsd:string |
| http://purl.uniprot.org/citations/29540318 | http://purl.uniprot.org/core/author | "Metheetrairut C."xsd:string |
| http://purl.uniprot.org/citations/29540318 | http://purl.uniprot.org/core/author | "Suthammarak W."xsd:string |
| http://purl.uniprot.org/citations/29540318 | http://purl.uniprot.org/core/author | "Boonchuay P."xsd:string |
| http://purl.uniprot.org/citations/29540318 | http://purl.uniprot.org/core/author | "Boonyatistan W."xsd:string |
| http://purl.uniprot.org/citations/29540318 | http://purl.uniprot.org/core/author | "Chuaijit S."xsd:string |
| http://purl.uniprot.org/citations/29540318 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/29540318 | http://purl.uniprot.org/core/name | "Mitochondrion"xsd:string |
| http://purl.uniprot.org/citations/29540318 | http://purl.uniprot.org/core/pages | "91-96"xsd:string |
| http://purl.uniprot.org/citations/29540318 | http://purl.uniprot.org/core/title | "Identification of a novel mitochondrial complex I assembly factor ACDH-12 in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/29540318 | http://purl.uniprot.org/core/volume | "46"xsd:string |
| http://purl.uniprot.org/citations/29540318 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29540318 |
| http://purl.uniprot.org/citations/29540318 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29540318 |
| http://purl.uniprot.org/uniprot/#_Q19057-mappedCitation-29540318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29540318 |
| http://purl.uniprot.org/uniprot/Q19057 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29540318 |