| http://purl.uniprot.org/citations/29540552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29540552 | http://www.w3.org/2000/01/rdf-schema#comment | "The c-Jun N-terminal kinase (JNK) signal transduction pathway is implicated in learning and memory. Here, we examined the role of JNK activation mediated by the JNK-interacting protein 1 (JIP1) scaffold protein. We compared male wild-type mice with a mouse model harboring a point mutation in the Jip1 gene that selectively blocks JIP1-mediated JNK activation. These male mutant mice exhibited increased NMDAR currents, increased NMDAR-mediated gene expression, and a lower threshold for induction of hippocampal long-term potentiation. The JIP1 mutant mice also displayed improved hippocampus-dependent spatial memory and enhanced associative fear conditioning. These results were confirmed using a second JIP1 mutant mouse model that suppresses JNK activity. Together, these observations establish that JIP1-mediated JNK activation contributes to the regulation of hippocampus-dependent, NMDAR-mediated synaptic plasticity and learning.SIGNIFICANCE STATEMENT The results of this study demonstrate that c-Jun N-terminal kinase (JNK) activation induced by the JNK-interacting protein 1 (JIP1) scaffold protein negatively regulates the threshold for induction of long-term synaptic plasticity through the NMDA-type glutamate receptor. This change in plasticity threshold influences learning. Indeed, mice with defects in JIP1-mediated JNK activation display enhanced memory in hippocampus-dependent tasks, such as contextual fear conditioning and Morris water maze, indicating that JIP1-JNK constrains spatial memory. This study identifies JIP1-mediated JNK activation as a novel molecular pathway that negatively regulates NMDAR-dependent synaptic plasticity and memory."xsd:string |
| http://purl.uniprot.org/citations/29540552 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.1913-17.2018"xsd:string |
| http://purl.uniprot.org/citations/29540552 | http://purl.uniprot.org/core/author | "Standen C.L."xsd:string |
| http://purl.uniprot.org/citations/29540552 | http://purl.uniprot.org/core/author | "Kennedy N.J."xsd:string |
| http://purl.uniprot.org/citations/29540552 | http://purl.uniprot.org/core/author | "Davis R.J."xsd:string |
| http://purl.uniprot.org/citations/29540552 | http://purl.uniprot.org/core/author | "Morel C."xsd:string |
| http://purl.uniprot.org/citations/29540552 | http://purl.uniprot.org/core/author | "Sherrin T."xsd:string |
| http://purl.uniprot.org/citations/29540552 | http://purl.uniprot.org/core/author | "Benveniste M."xsd:string |
| http://purl.uniprot.org/citations/29540552 | http://purl.uniprot.org/core/author | "Nichols R.A."xsd:string |
| http://purl.uniprot.org/citations/29540552 | http://purl.uniprot.org/core/author | "Robles M."xsd:string |
| http://purl.uniprot.org/citations/29540552 | http://purl.uniprot.org/core/author | "Todorovic C."xsd:string |
| http://purl.uniprot.org/citations/29540552 | http://purl.uniprot.org/core/author | "Carpenter-Hyland E."xsd:string |
| http://purl.uniprot.org/citations/29540552 | http://purl.uniprot.org/core/author | "Alfulaij N."xsd:string |
| http://purl.uniprot.org/citations/29540552 | http://purl.uniprot.org/core/author | "Forest K.H."xsd:string |
| http://purl.uniprot.org/citations/29540552 | http://purl.uniprot.org/core/author | "Avcioglu Barutcu S."xsd:string |
| http://purl.uniprot.org/citations/29540552 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29540552 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/29540552 | http://purl.uniprot.org/core/pages | "3708-3728"xsd:string |
| http://purl.uniprot.org/citations/29540552 | http://purl.uniprot.org/core/title | "JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory."xsd:string |
| http://purl.uniprot.org/citations/29540552 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/29540552 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29540552 |
| http://purl.uniprot.org/citations/29540552 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29540552 |
| http://purl.uniprot.org/uniprot/#_Q3UI81-mappedCitation-29540552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29540552 |
| http://purl.uniprot.org/uniprot/#_Q6GQW8-mappedCitation-29540552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29540552 |