| http://purl.uniprot.org/citations/29540618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29540618 | http://www.w3.org/2000/01/rdf-schema#comment | "Mesenchymal stem cells (MSCs) are capable of secreting exosomes, extracellular vesicles, and cytokines to regulate cell and tissue homeostasis. However, it is unknown whether MSCs use a specific exocytotic fusion mechanism to secrete exosomes and cytokines. We show that Fas binds with Fas-associated phosphatase-1 (Fap-1) and caveolin-1 (Cav-1) to activate a common soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor (SNARE)-mediated membrane fusion mechanism to release small extracellular vesicles (sEVs) in MSCs. Moreover, we reveal that MSCs produce and secrete interleukin-1 receptor antagonist (IL-1RA) associated with sEVs to maintain rapid wound healing in the gingiva via the Fas/Fap-1/Cav-1 cascade. Tumor necrosis factor-α (TNF-α) serves as an activator to up-regulate Fas and Fap-1 expression via the nuclear factor κB pathway to promote IL-1RA release. This study identifies a previously unknown Fas/Fap-1/Cav-1 axis that regulates SNARE-mediated sEV and IL-1RA secretion in stem cells, which contributes to accelerated wound healing."xsd:string |
| http://purl.uniprot.org/citations/29540618 | http://purl.org/dc/terms/identifier | "doi:10.1126/scitranslmed.aai8524"xsd:string |
| http://purl.uniprot.org/citations/29540618 | http://purl.uniprot.org/core/author | "Chen C."xsd:string |
| http://purl.uniprot.org/citations/29540618 | http://purl.uniprot.org/core/author | "Cai T."xsd:string |
| http://purl.uniprot.org/citations/29540618 | http://purl.uniprot.org/core/author | "Le A."xsd:string |
| http://purl.uniprot.org/citations/29540618 | http://purl.uniprot.org/core/author | "Xu X."xsd:string |
| http://purl.uniprot.org/citations/29540618 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/29540618 | http://purl.uniprot.org/core/author | "Shi S."xsd:string |
| http://purl.uniprot.org/citations/29540618 | http://purl.uniprot.org/core/author | "Kou X."xsd:string |
| http://purl.uniprot.org/citations/29540618 | http://purl.uniprot.org/core/author | "Giraudo C."xsd:string |
| http://purl.uniprot.org/citations/29540618 | http://purl.uniprot.org/core/author | "Sanmillan M.L."xsd:string |
| http://purl.uniprot.org/citations/29540618 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29540618 | http://purl.uniprot.org/core/name | "Sci Transl Med"xsd:string |
| http://purl.uniprot.org/citations/29540618 | http://purl.uniprot.org/core/pages | "eaai8524"xsd:string |
| http://purl.uniprot.org/citations/29540618 | http://purl.uniprot.org/core/title | "The Fas/Fap-1/Cav-1 complex regulates IL-1RA secretion in mesenchymal stem cells to accelerate wound healing."xsd:string |
| http://purl.uniprot.org/citations/29540618 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/29540618 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29540618 |
| http://purl.uniprot.org/citations/29540618 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29540618 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVU4-mappedCitation-29540618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29540618 |
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| http://purl.uniprot.org/uniprot/#_D3Z148-mappedCitation-29540618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29540618 |
| http://purl.uniprot.org/uniprot/#_A0A494BBE8-mappedCitation-29540618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29540618 |
| http://purl.uniprot.org/uniprot/#_A0A494BBP5-mappedCitation-29540618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29540618 |
| http://purl.uniprot.org/uniprot/#_A1Y9B2-mappedCitation-29540618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29540618 |