| http://purl.uniprot.org/citations/29541409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29541409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29541409 | http://www.w3.org/2000/01/rdf-schema#comment | "Androgen deprivation therapy (ADT) is palliative and prostate cancer (CaP) recurs as lethal castration-recurrent/resistant CaP (CRPC). One mechanism that provides CaP resistance to ADT is primary backdoor androgen metabolism, which uses up to four 3α-oxidoreductases to convert 5α-androstane-3α,17β-diol (DIOL) to dihydrotestosterone (DHT). The goal was to determine whether inhibition of 3α-oxidoreductase activity decreased conversion of DIOL to DHT. Protein sequence analysis showed that the four 3α-oxidoreductases have identical catalytic amino acid residues. Mass spectrometry data showed combined treatment using catalytically inactive 3α-oxidoreductase mutants and the 5α-reductase inhibitor, dutasteride, decreased DHT levels in CaP cells better than dutasteride alone. Combined blockade of frontdoor and backdoor pathways of DHT synthesis provides a therapeutic strategy to inhibit CRPC development and growth."xsd:string |
| http://purl.uniprot.org/citations/29541409 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.24107"xsd:string |
| http://purl.uniprot.org/citations/29541409 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.24107"xsd:string |
| http://purl.uniprot.org/citations/29541409 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/29541409 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/29541409 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/29541409 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/29541409 | http://purl.uniprot.org/core/author | "Wilson E.M."xsd:string |
| http://purl.uniprot.org/citations/29541409 | http://purl.uniprot.org/core/author | "Wilson E.M."xsd:string |
| http://purl.uniprot.org/citations/29541409 | http://purl.uniprot.org/core/author | "Mohler J.L."xsd:string |
| http://purl.uniprot.org/citations/29541409 | http://purl.uniprot.org/core/author | "Mohler J.L."xsd:string |
| http://purl.uniprot.org/citations/29541409 | http://purl.uniprot.org/core/author | "Watt D.S."xsd:string |
| http://purl.uniprot.org/citations/29541409 | http://purl.uniprot.org/core/author | "Watt D.S."xsd:string |
| http://purl.uniprot.org/citations/29541409 | http://purl.uniprot.org/core/author | "Attwood K.M."xsd:string |
| http://purl.uniprot.org/citations/29541409 | http://purl.uniprot.org/core/author | "Attwood K.M."xsd:string |
| http://purl.uniprot.org/citations/29541409 | http://purl.uniprot.org/core/author | "Azabdaftari G."xsd:string |
| http://purl.uniprot.org/citations/29541409 | http://purl.uniprot.org/core/author | "Azabdaftari G."xsd:string |
| http://purl.uniprot.org/citations/29541409 | http://purl.uniprot.org/core/author | "Fiandalo M.V."xsd:string |
| http://purl.uniprot.org/citations/29541409 | http://purl.uniprot.org/core/author | "Fiandalo M.V."xsd:string |
| http://purl.uniprot.org/citations/29541409 | http://purl.uniprot.org/core/author | "Mantione K.M."xsd:string |
| http://purl.uniprot.org/citations/29541409 | http://purl.uniprot.org/core/author | "Mantione K.M."xsd:string |
| http://purl.uniprot.org/citations/29541409 | http://purl.uniprot.org/core/author | "Pop E.A."xsd:string |
| http://purl.uniprot.org/citations/29541409 | http://purl.uniprot.org/core/author | "Pop E.A."xsd:string |