| http://purl.uniprot.org/citations/29549917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29549917 | http://www.w3.org/2000/01/rdf-schema#comment | "We aimed to evaluate the longitudinal interaction effects between the minor allele of FADS1 rs174547 and overweight on n-3 and n-6 long-chain polyunsaturated fatty acid (PUFA) levels and pulse wave velocity (PWV). Plasma PUFA levels were measured via GC-MS, and arterial stiffness was determined as brachial-ankle PWV (ba-PWV) at baseline and after a mean follow-up of 3 years. The FADS1 rs174547 T > C genotype was analyzed. At 3-years of follow-up, after adjustment for age, sex, smoking and drinking, there were interaction effects between the FADS1 rs174547 T > C genotype and baseline BMI on the changes (from baseline) in plasma arachidonic acid (AA) levels, in the eicosapentaenoic acid (EPA)/AA ratio, and in ba-PWV (p for interaction = 0.036, 0.022, and 0.001, respectively). There were smaller increases in AA levels from baseline among normal-weight C allele carriers (n = 112) and overweight TT subjects (n = 47) than among normal-weight TT subjects (n = 91). Overweight C allele carriers (n = 37) showed greater reductions in the plasma EPA/AA ratio and greater increases in ba-PWV than the 3 other populations studied. The minor allele of the FADS1 rs174547 polymorphism is associated with age-related decreases in the EPA/AA ratio and increases in ba-PWV among overweight subjects."xsd:string |
| http://purl.uniprot.org/citations/29549917 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.plefa.2018.02.004"xsd:string |
| http://purl.uniprot.org/citations/29549917 | http://purl.uniprot.org/core/author | "Kim M."xsd:string |
| http://purl.uniprot.org/citations/29549917 | http://purl.uniprot.org/core/author | "Lee J.H."xsd:string |
| http://purl.uniprot.org/citations/29549917 | http://purl.uniprot.org/core/author | "Lee A."xsd:string |
| http://purl.uniprot.org/citations/29549917 | http://purl.uniprot.org/core/author | "Yoo H.J."xsd:string |
| http://purl.uniprot.org/citations/29549917 | http://purl.uniprot.org/core/author | "Jeong S."xsd:string |
| http://purl.uniprot.org/citations/29549917 | http://purl.uniprot.org/core/author | "Kim M.'"xsd:string |
| http://purl.uniprot.org/citations/29549917 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29549917 | http://purl.uniprot.org/core/name | "Prostaglandins Leukot Essent Fatty Acids"xsd:string |
| http://purl.uniprot.org/citations/29549917 | http://purl.uniprot.org/core/pages | "11-18"xsd:string |
| http://purl.uniprot.org/citations/29549917 | http://purl.uniprot.org/core/title | "Associations among FADS1 rs174547, eicosapentaenoic acid/arachidonic acid ratio, and arterial stiffness in overweight subjects."xsd:string |
| http://purl.uniprot.org/citations/29549917 | http://purl.uniprot.org/core/volume | "130"xsd:string |
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