| http://purl.uniprot.org/citations/29549963 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29549963 | http://www.w3.org/2000/01/rdf-schema#comment | "T-cell-mediated destruction of pancreatic β cells leads to Type 1 diabetes (TID). Vitamin D-Binding Protein (VDBP) has been identified as an autoantigen and T cell reactivity against VDBP increases in the development of T1D. Autoreactive cytotoxic T lymphocytes (CTLs) recognize β-cell-derived peptides in the context of major histocompatibility complex class I molecules. However, little is known about the VDBP-derived immunogenic peptides that are presented in the context of human HLA molecules. Here, we predicted and identified VDBP derived immunogenic peptides that were presented in association with human HLA-A2 molecule. The VDBP derived peptides binding to HLA-A∗0201 were predicted by using a computer-assisted algorithm. The candidate peptides were synthesized, then affinity between peptides and HLA-A∗0201 were analyzed. In addition, the CTL activity of the peptides was detected by cytotoxicity assay and ELISPOT assay in vitro. Furthermore, HLA-A∗0201-transgenic mice were immunized with peptides to induce the CTL activity in vivo. The results demonstrated that peptides of VDBP containing residues 211-219 and 235-243 had high affinity with HLA-A∗0201. In addition, these peptides elicited potent CTL responses in vitro, and induced T1D in vivo. Therefore, this experiment identified immunogenic HLA-A∗0201-restricted epitopes derived from VDBP, and provided pathogenesis theory of T1D."xsd:string |
| http://purl.uniprot.org/citations/29549963 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellimm.2018.03.002"xsd:string |
| http://purl.uniprot.org/citations/29549963 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/29549963 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/29549963 | http://purl.uniprot.org/core/author | "Lu G."xsd:string |
| http://purl.uniprot.org/citations/29549963 | http://purl.uniprot.org/core/author | "Gong X."xsd:string |
| http://purl.uniprot.org/citations/29549963 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/29549963 | http://purl.uniprot.org/core/author | "Meng F."xsd:string |
| http://purl.uniprot.org/citations/29549963 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29549963 | http://purl.uniprot.org/core/name | "Cell Immunol"xsd:string |
| http://purl.uniprot.org/citations/29549963 | http://purl.uniprot.org/core/pages | "18-23"xsd:string |
| http://purl.uniprot.org/citations/29549963 | http://purl.uniprot.org/core/title | "Identification of HLA-A2-restricted immunogenic peptides derived from Vitamin D-Binding Protein."xsd:string |
| http://purl.uniprot.org/citations/29549963 | http://purl.uniprot.org/core/volume | "328"xsd:string |
| http://purl.uniprot.org/citations/29549963 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29549963 |
| http://purl.uniprot.org/citations/29549963 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29549963 |
| http://purl.uniprot.org/uniprot/#_D6RBJ7-mappedCitation-29549963 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29549963 |
| http://purl.uniprot.org/uniprot/D6RBJ7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29549963 |