| http://purl.uniprot.org/citations/29550816 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29550816 | http://www.w3.org/2000/01/rdf-schema#comment | "BACKGROUND/AIMS:An increasing number of studies have linked erythropoietin-producing hepatocellular carcinoma (Eph) family receptor tyrosine kinases to cancer progression. However, little knowledge is available about the regulation of their functions in cancer. METHODS:SUMOylation was analyzed by performing Ni2+-NTA pull-down assay and immunoprecipitation. Cell proliferation, anchorage-independent growth, and tumorigenesis in vivo were examined by cell counting kit-8, soft agar colony formation assay, and a xenograft tumor mouse model, respectively. RESULTS:We found that EphB1 was post-translationally modified by the small ubiquitin-like modifier (SUMO) protein at lysine residue 785. Analysis of wild-type EphB1 and SUMOylation-deficient EphB1 K785R mutant revealed that SUMOylation of EphB1 suppressed cell proliferation, anchorage-independent cell growth, and xenograft tumor growth. Mechanistic study showed that SUMOylation of EphB1 repressed activation of its downstream signaling molecule PKCγ, and consequently inhibited tumorigenesis. A reciprocal regulatory loop between PKCγ and SUMOylation of EphB1 was also characterized. CONCLUSION:Our findings identify SUMO1 as a novel key regulator of EphB1-mediated tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/29550816 | http://purl.org/dc/terms/identifier | "doi:10.1159/000488174"xsd:string |
| http://purl.uniprot.org/citations/29550816 | http://purl.uniprot.org/core/author | "Chen R."xsd:string |
| http://purl.uniprot.org/citations/29550816 | http://purl.uniprot.org/core/author | "Chen Q."xsd:string |
| http://purl.uniprot.org/citations/29550816 | http://purl.uniprot.org/core/author | "Jin H."xsd:string |
| http://purl.uniprot.org/citations/29550816 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/29550816 | http://purl.uniprot.org/core/author | "Deng R."xsd:string |
| http://purl.uniprot.org/citations/29550816 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/29550816 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/29550816 | http://purl.uniprot.org/core/author | "Yu J."xsd:string |
| http://purl.uniprot.org/citations/29550816 | http://purl.uniprot.org/core/author | "Zhao X."xsd:string |
| http://purl.uniprot.org/citations/29550816 | http://purl.uniprot.org/core/author | "Yuan H."xsd:string |
| http://purl.uniprot.org/citations/29550816 | http://purl.uniprot.org/core/author | "Dou J."xsd:string |
| http://purl.uniprot.org/citations/29550816 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29550816 | http://purl.uniprot.org/core/name | "Cell Physiol Biochem"xsd:string |
| http://purl.uniprot.org/citations/29550816 | http://purl.uniprot.org/core/pages | "2283-2292"xsd:string |
| http://purl.uniprot.org/citations/29550816 | http://purl.uniprot.org/core/title | "Sumoylation of EphB1 Suppresses Neuroblastoma Tumorigenesis via Inhibiting PKCgamma Activation."xsd:string |
| http://purl.uniprot.org/citations/29550816 | http://purl.uniprot.org/core/volume | "45"xsd:string |
| http://purl.uniprot.org/citations/29550816 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29550816 |
| http://purl.uniprot.org/citations/29550816 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29550816 |
| http://purl.uniprot.org/uniprot/#_B2R5T1-mappedCitation-29550816 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29550816 |
| http://purl.uniprot.org/uniprot/#_A0A804HIU5-mappedCitation-29550816 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29550816 |
| http://purl.uniprot.org/uniprot/#_B7Z3V9-mappedCitation-29550816 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29550816 |
| http://purl.uniprot.org/uniprot/#_B7Z3W6-mappedCitation-29550816 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29550816 |