| http://purl.uniprot.org/citations/29557065 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29557065 | http://www.w3.org/2000/01/rdf-schema#comment | "Assembly of eukaryotic ribosome is a complicated and dynamic process that involves a series of intermediates. It is unknown how the highly intertwined structure of 60S large ribosomal subunits is established. Here, we report the structure of an early nucleolar pre-60S ribosome determined by cryo-electron microscopy at 3.7 Å resolution, revealing a half-assembled subunit. Domains I, II and VI of 25S/5.8S rRNA pack tightly into a native-like substructure, but domains III, IV and V are not assembled. The structure contains 12 assembly factors and 19 ribosomal proteins, many of which are required for early processing of large subunit rRNA. The Brx1-Ebp2 complex would interfere with the assembly of domains IV and V. Rpf1, Mak16, Nsa1 and Rrp1 form a cluster that consolidates the joining of domains I and II. Our structure reveals a key intermediate on the path to establishing the global architecture of 60S subunits."xsd:string |
| http://purl.uniprot.org/citations/29557065 | http://purl.org/dc/terms/identifier | "doi:10.1007/s13238-018-0526-7"xsd:string |
| http://purl.uniprot.org/citations/29557065 | http://purl.uniprot.org/core/author | "Zhu X."xsd:string |
| http://purl.uniprot.org/citations/29557065 | http://purl.uniprot.org/core/author | "Ye K."xsd:string |
| http://purl.uniprot.org/citations/29557065 | http://purl.uniprot.org/core/author | "Zhou D."xsd:string |
| http://purl.uniprot.org/citations/29557065 | http://purl.uniprot.org/core/author | "Dong M.Q."xsd:string |
| http://purl.uniprot.org/citations/29557065 | http://purl.uniprot.org/core/author | "Zheng S."xsd:string |
| http://purl.uniprot.org/citations/29557065 | http://purl.uniprot.org/core/author | "Tan D."xsd:string |
| http://purl.uniprot.org/citations/29557065 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/29557065 | http://purl.uniprot.org/core/name | "Protein Cell"xsd:string |
| http://purl.uniprot.org/citations/29557065 | http://purl.uniprot.org/core/pages | "120-130"xsd:string |
| http://purl.uniprot.org/citations/29557065 | http://purl.uniprot.org/core/title | "Cryo-EM structure of an early precursor of large ribosomal subunit reveals a half-assembled intermediate."xsd:string |
| http://purl.uniprot.org/citations/29557065 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/29557065 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29557065 |
| http://purl.uniprot.org/citations/29557065 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29557065 |
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| http://purl.uniprot.org/uniprot/#_Q03532-mappedCitation-29557065 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29557065 |
| http://purl.uniprot.org/uniprot/#_P38061-mappedCitation-29557065 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29557065 |
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