| http://purl.uniprot.org/citations/29562174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29562174 | http://www.w3.org/2000/01/rdf-schema#comment | "Interferons (IFNs) and inflammasomes are essential mediators of anti-microbial immunity. Type I IFN signaling drives activation of the AIM2 inflammasome in macrophages; however, the relative contribution of IFNs and inflammasome responses in host defense is less understood. We report intact AIM2 inflammasome responses in mice lacking type I IFN signaling during infection with F. novicida. Lack of type I IFN signaling conferred protection to F. novicida infection in contrast to the increased susceptibility in AIM2-deficient mice. Mice lacking both AIM2 and IFNAR2 were protected against the infection. The detrimental effects of type I IFN signaling were due to its ability to induce activation of apoptotic caspases and cell death. These results demonstrate the contrasting effects of type I IFN signaling and AIM2 during F. novicida infection in vivo and indicate a dominant role for type I IFNs in mediating detrimental responses despite the protective AIM2 inflammasome responses."xsd:string |
| http://purl.uniprot.org/citations/29562174 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2018.02.096"xsd:string |
| http://purl.uniprot.org/citations/29562174 | http://purl.uniprot.org/core/author | "Zhu Q."xsd:string |
| http://purl.uniprot.org/citations/29562174 | http://purl.uniprot.org/core/author | "Kanneganti T.D."xsd:string |
| http://purl.uniprot.org/citations/29562174 | http://purl.uniprot.org/core/author | "Karki R."xsd:string |
| http://purl.uniprot.org/citations/29562174 | http://purl.uniprot.org/core/author | "Man S.M."xsd:string |
| http://purl.uniprot.org/citations/29562174 | http://purl.uniprot.org/core/author | "Malireddi R.K.S."xsd:string |
| http://purl.uniprot.org/citations/29562174 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29562174 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/29562174 | http://purl.uniprot.org/core/pages | "3168-3174"xsd:string |
| http://purl.uniprot.org/citations/29562174 | http://purl.uniprot.org/core/title | "Detrimental Type I Interferon Signaling Dominates Protective AIM2 Inflammasome Responses during Francisella novicida Infection."xsd:string |
| http://purl.uniprot.org/citations/29562174 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/29562174 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29562174 |
| http://purl.uniprot.org/citations/29562174 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29562174 |
| http://purl.uniprot.org/uniprot/#_A0A125R9I3-mappedCitation-29562174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29562174 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVY5-mappedCitation-29562174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29562174 |
| http://purl.uniprot.org/uniprot/#_E9PZJ2-mappedCitation-29562174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29562174 |
| http://purl.uniprot.org/uniprot/#_E9Q5T2-mappedCitation-29562174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29562174 |
| http://purl.uniprot.org/uniprot/#_P56477-mappedCitation-29562174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29562174 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRH7-mappedCitation-29562174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29562174 |
| http://purl.uniprot.org/uniprot/#_A0A2R3XZC4-mappedCitation-29562174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29562174 |
| http://purl.uniprot.org/uniprot/#_A0A494B980-mappedCitation-29562174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29562174 |
| http://purl.uniprot.org/uniprot/#_A0A2U8RP79-mappedCitation-29562174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29562174 |
| http://purl.uniprot.org/uniprot/#_A0A338P6T9-mappedCitation-29562174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29562174 |