| http://purl.uniprot.org/citations/29565969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29565969 | http://www.w3.org/2000/01/rdf-schema#comment | "Opacification of the ocular lens, termed cataract, is a common cause of blindness. To become transparent, lens fiber cells undergo degradation of their organelles, including their nuclei, presenting a fundamental question: does signaling/transcription sufficiently explain differentiation of cells progressing toward compromised transcriptional potential? We report that a conserved RNA-binding protein Celf1 post-transcriptionally controls key genes to regulate lens fiber cell differentiation. Celf1-targeted knockout mice and celf1-knockdown zebrafish and Xenopus morphants have severe eye defects/cataract. Celf1 spatiotemporally down-regulates the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 by interacting with its 5' UTR and mediating translation inhibition. Celf1 deficiency causes ectopic up-regulation of p21Cip1. Further, Celf1 directly binds to the mRNA of the nuclease Dnase2b to maintain its high levels. Together these events are necessary for Cdk1-mediated lamin A/C phosphorylation to initiate nuclear envelope breakdown and DNA degradation in fiber cells. Moreover, Celf1 controls alternative splicing of the membrane-organization factor beta-spectrin and regulates F-actin-crosslinking factor Actn2 mRNA levels, thereby controlling fiber cell morphology. Thus, we illustrate new Celf1-regulated molecular mechanisms in lens development, suggesting that post-transcriptional regulatory RNA-binding proteins have evolved conserved functions to control vertebrate oculogenesis."xsd:string |
| http://purl.uniprot.org/citations/29565969 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1007278"xsd:string |
| http://purl.uniprot.org/citations/29565969 | http://purl.uniprot.org/core/author | "Lachke S.A."xsd:string |
| http://purl.uniprot.org/citations/29565969 | http://purl.uniprot.org/core/author | "Gautier-Courteille C."xsd:string |
| http://purl.uniprot.org/citations/29565969 | http://purl.uniprot.org/core/author | "Legagneux V."xsd:string |
| http://purl.uniprot.org/citations/29565969 | http://purl.uniprot.org/core/author | "Paillard L."xsd:string |
| http://purl.uniprot.org/citations/29565969 | http://purl.uniprot.org/core/author | "Anand D."xsd:string |
| http://purl.uniprot.org/citations/29565969 | http://purl.uniprot.org/core/author | "Gross J.M."xsd:string |
| http://purl.uniprot.org/citations/29565969 | http://purl.uniprot.org/core/author | "Viet J."xsd:string |
| http://purl.uniprot.org/citations/29565969 | http://purl.uniprot.org/core/author | "Mereau A."xsd:string |
| http://purl.uniprot.org/citations/29565969 | http://purl.uniprot.org/core/author | "Kakrana A."xsd:string |
| http://purl.uniprot.org/citations/29565969 | http://purl.uniprot.org/core/author | "Dang C.A."xsd:string |
| http://purl.uniprot.org/citations/29565969 | http://purl.uniprot.org/core/author | "Siddam A.D."xsd:string |
| http://purl.uniprot.org/citations/29565969 | http://purl.uniprot.org/core/author | "Perez-Campos L."xsd:string |
| http://purl.uniprot.org/citations/29565969 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29565969 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/29565969 | http://purl.uniprot.org/core/pages | "e1007278"xsd:string |
| http://purl.uniprot.org/citations/29565969 | http://purl.uniprot.org/core/title | "The RNA-binding protein Celf1 post-transcriptionally regulates p27Kip1 and Dnase2b to control fiber cell nuclear degradation in lens development."xsd:string |
| http://purl.uniprot.org/citations/29565969 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/29565969 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29565969 |
| http://purl.uniprot.org/citations/29565969 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29565969 |
| http://purl.uniprot.org/uniprot/Q9IBD0#attribution-F39FD830397DF63EF688CA9EBC8CA4C9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/29565969 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0T5-mappedCitation-29565969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29565969 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VMW4-mappedCitation-29565969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29565969 |