| http://purl.uniprot.org/citations/29576450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29576450 | http://www.w3.org/2000/01/rdf-schema#comment | "Hereditary xerocytosis is thought to be a rare genetic condition characterized by red blood cell (RBC) dehydration with mild hemolysis. RBC dehydration is linked to reduced Plasmodium infection in vitro; however, the role of RBC dehydration in protection against malaria in vivo is unknown. Most cases of hereditary xerocytosis are associated with gain-of-function mutations in PIEZO1, a mechanically activated ion channel. We engineered a mouse model of hereditary xerocytosis and show that Plasmodium infection fails to cause experimental cerebral malaria in these mice due to the action of Piezo1 in RBCs and in T cells. Remarkably, we identified a novel human gain-of-function PIEZO1 allele, E756del, present in a third of the African population. RBCs from individuals carrying this allele are dehydrated and display reduced Plasmodium infection in vitro. The existence of a gain-of-function PIEZO1 at such high frequencies is surprising and suggests an association with malaria resistance."xsd:string |
| http://purl.uniprot.org/citations/29576450 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2018.02.047"xsd:string |
| http://purl.uniprot.org/citations/29576450 | http://purl.uniprot.org/core/author | "Ma S."xsd:string |
| http://purl.uniprot.org/citations/29576450 | http://purl.uniprot.org/core/author | "Janse C.J."xsd:string |
| http://purl.uniprot.org/citations/29576450 | http://purl.uniprot.org/core/author | "Khan S.M."xsd:string |
| http://purl.uniprot.org/citations/29576450 | http://purl.uniprot.org/core/author | "Winzeler E.A."xsd:string |
| http://purl.uniprot.org/citations/29576450 | http://purl.uniprot.org/core/author | "Zeng W."xsd:string |
| http://purl.uniprot.org/citations/29576450 | http://purl.uniprot.org/core/author | "Berry L."xsd:string |
| http://purl.uniprot.org/citations/29576450 | http://purl.uniprot.org/core/author | "Wengelnik K."xsd:string |
| http://purl.uniprot.org/citations/29576450 | http://purl.uniprot.org/core/author | "Su A.I."xsd:string |
| http://purl.uniprot.org/citations/29576450 | http://purl.uniprot.org/core/author | "Murthy S.E."xsd:string |
| http://purl.uniprot.org/citations/29576450 | http://purl.uniprot.org/core/author | "Patapoutian A."xsd:string |
| http://purl.uniprot.org/citations/29576450 | http://purl.uniprot.org/core/author | "Schmedt C."xsd:string |
| http://purl.uniprot.org/citations/29576450 | http://purl.uniprot.org/core/author | "Whitwam T."xsd:string |
| http://purl.uniprot.org/citations/29576450 | http://purl.uniprot.org/core/author | "Honore E."xsd:string |
| http://purl.uniprot.org/citations/29576450 | http://purl.uniprot.org/core/author | "Bandell M."xsd:string |
| http://purl.uniprot.org/citations/29576450 | http://purl.uniprot.org/core/author | "Cahalan S."xsd:string |
| http://purl.uniprot.org/citations/29576450 | http://purl.uniprot.org/core/author | "Grubaugh N.D."xsd:string |
| http://purl.uniprot.org/citations/29576450 | http://purl.uniprot.org/core/author | "Andersen K.G."xsd:string |
| http://purl.uniprot.org/citations/29576450 | http://purl.uniprot.org/core/author | "LaMonte G."xsd:string |
| http://purl.uniprot.org/citations/29576450 | http://purl.uniprot.org/core/author | "Lukacs V."xsd:string |
| http://purl.uniprot.org/citations/29576450 | http://purl.uniprot.org/core/author | "Lohia R."xsd:string |
| http://purl.uniprot.org/citations/29576450 | http://purl.uniprot.org/core/author | "Gamini R."xsd:string |
| http://purl.uniprot.org/citations/29576450 | http://purl.uniprot.org/core/author | "Loud M."xsd:string |