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Purpose

Recent studies indicate that the effects of interleukin 6 (IL-6) realized via soluble IL-6 receptor (sIL-6R) facilitate the development of various pathological processes. Soluble gp130 (sgp130) is a naturally occurring inhibitor of signal transduction via this pathway. In this study, we assessed the relationship between circulating levels of IL-6, sIL-6R and sgp130 and severity of coronary atherosclerosis in patients with stable coronary artery disease (CAD).

Methods

Plasma levels of IL-6, sIL-6R and sgp130 were measured in patients with atherosclerotic coronary lesions (n = 128, group 1) and with intact coronary arteries (n = 48, group 2). The severity of coronary atherosclerosis was evaluated by the number of affected arteries and by Gensini Score index.

Results

Circulating IL-6 levels in group 1 were significantly higher than those in group 2. The levels of sIL-6R did not differ considerably in both the groups. The levels of sgp130 in group 1 were significantly lower than in group 2. A negative correlation has been revealed between sgp130 levels and the number of affected coronary arteries and Gensini Score index.

Conclusions

Serum concentration of sgp130 in patients with stable CAD is inversely related to severity of coronary damage. Low sgp130 level may serve as an additional indicator of coronary atherosclerosis severity."xsd:string
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http://purl.uniprot.org/citations/29580104http://purl.uniprot.org/core/author"Prokazova N.V."xsd:string
http://purl.uniprot.org/citations/29580104http://purl.uniprot.org/core/author"Korotaeva A.A."xsd:string
http://purl.uniprot.org/citations/29580104http://purl.uniprot.org/core/author"Samoilova E.V."xsd:string
http://purl.uniprot.org/citations/29580104http://purl.uniprot.org/core/author"Shuvalova Y.A."xsd:string
http://purl.uniprot.org/citations/29580104http://purl.uniprot.org/core/author"Chepurnova D.A."xsd:string
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http://purl.uniprot.org/citations/29580104http://purl.uniprot.org/core/title"Soluble glycoprotein 130 is inversely related to severity of coronary atherosclerosis."xsd:string
http://purl.uniprot.org/citations/29580104http://purl.uniprot.org/core/volume"23"xsd:string
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