| http://purl.uniprot.org/citations/29580920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29580920 | http://www.w3.org/2000/01/rdf-schema#comment | "Antioxidants were long predicted to have lifespan-promoting effects, but in general this prediction has not been well supported. While some antioxidants do seem to have a clear effect on longevity, this may not be primarily as a result of their role in the removal of reactive oxygen species, but rather mediated by other mechanisms such as the modulation of intracellular signaling. In this review we discuss peroxiredoxins, a class of proteinaceous antioxidants with redox signaling and chaperone functions, and their involvement in regulating longevity and stress resistance. Peroxiredoxins have a clear role in the regulation of lifespan and survival of many model organisms, including the mouse, Caenorhabditis elegans and Drosophila melanogaster. Recent research on peroxiredoxins - in these models and beyond - has revealed surprising new insights regarding the interplay between peroxiredoxins and longevity signaling, which will be discussed here in detail. As redox signaling is emerging as a potentially important player in the regulation of longevity and aging, increased knowledge of these fascinating antioxidants and their mode(s) of action is paramount."xsd:string |
| http://purl.uniprot.org/citations/29580920 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.arr.2018.03.005"xsd:string |
| http://purl.uniprot.org/citations/29580920 | http://purl.uniprot.org/core/author | "Edwards S.L."xsd:string |
| http://purl.uniprot.org/citations/29580920 | http://purl.uniprot.org/core/author | "Temmerman L."xsd:string |
| http://purl.uniprot.org/citations/29580920 | http://purl.uniprot.org/core/author | "De Haes W."xsd:string |
| http://purl.uniprot.org/citations/29580920 | http://purl.uniprot.org/core/author | "Detienne G."xsd:string |
| http://purl.uniprot.org/citations/29580920 | http://purl.uniprot.org/core/author | "Van Bael S."xsd:string |
| http://purl.uniprot.org/citations/29580920 | http://purl.uniprot.org/core/author | "Mergan L."xsd:string |
| http://purl.uniprot.org/citations/29580920 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29580920 | http://purl.uniprot.org/core/name | "Ageing Res Rev"xsd:string |
| http://purl.uniprot.org/citations/29580920 | http://purl.uniprot.org/core/pages | "33-48"xsd:string |
| http://purl.uniprot.org/citations/29580920 | http://purl.uniprot.org/core/title | "Beyond ROS clearance: Peroxiredoxins in stress signaling and aging."xsd:string |
| http://purl.uniprot.org/citations/29580920 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/29580920 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29580920 |
| http://purl.uniprot.org/citations/29580920 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29580920 |
| http://purl.uniprot.org/uniprot/#_A1Z892-mappedCitation-29580920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29580920 |
| http://purl.uniprot.org/uniprot/#_Q7JX87-mappedCitation-29580920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29580920 |
| http://purl.uniprot.org/uniprot/#_Q95SB0-mappedCitation-29580920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29580920 |
| http://purl.uniprot.org/uniprot/#_Q960M4-mappedCitation-29580920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29580920 |
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| http://purl.uniprot.org/uniprot/#_Q9V3Q4-mappedCitation-29580920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29580920 |
| http://purl.uniprot.org/uniprot/#_Q9GPQ0-mappedCitation-29580920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29580920 |
| http://purl.uniprot.org/uniprot/#_Q9GPQ1-mappedCitation-29580920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29580920 |
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