| http://purl.uniprot.org/citations/29587144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29587144 | http://www.w3.org/2000/01/rdf-schema#comment | "The intestine has direct contact with nutritional information. The mechanisms by which particular dietary molecules affect intestinal homeostasis are not fully understood. In this study, we identified S-adenosylmethionine (SAM), a universal methyl donor synthesized from dietary methionine, as a critical molecule that regulates stem cell division in Drosophila midgut. Depletion of either dietary methionine or SAM synthesis reduces division rate of intestinal stem cells. Genetic screening for putative SAM-dependent methyltransferases has identified protein synthesis as a regulator of the stem cells, partially through a unique diphthamide modification on eukaryotic elongation factor 2. In contrast, SAM in nutrient-absorptive enterocytes controls the interleukin-6-like protein Unpaired 3, which is required for rapid division of the stem cells after refeeding. Our study sheds light upon a link between diet and intestinal homeostasis and highlights the key metabolite SAM as a mediator of cell-type-specific starvation response."xsd:string |
| http://purl.uniprot.org/citations/29587144 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2018.02.017"xsd:string |
| http://purl.uniprot.org/citations/29587144 | http://purl.uniprot.org/core/author | "Kimura M."xsd:string |
| http://purl.uniprot.org/citations/29587144 | http://purl.uniprot.org/core/author | "Funakoshi M."xsd:string |
| http://purl.uniprot.org/citations/29587144 | http://purl.uniprot.org/core/author | "Nishimura K."xsd:string |
| http://purl.uniprot.org/citations/29587144 | http://purl.uniprot.org/core/author | "Yamazaki T."xsd:string |
| http://purl.uniprot.org/citations/29587144 | http://purl.uniprot.org/core/author | "Miura M."xsd:string |
| http://purl.uniprot.org/citations/29587144 | http://purl.uniprot.org/core/author | "Obata F."xsd:string |
| http://purl.uniprot.org/citations/29587144 | http://purl.uniprot.org/core/author | "Nishio R."xsd:string |
| http://purl.uniprot.org/citations/29587144 | http://purl.uniprot.org/core/author | "Tsuda-Sakurai K."xsd:string |
| http://purl.uniprot.org/citations/29587144 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29587144 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/29587144 | http://purl.uniprot.org/core/pages | "741-751.e3"xsd:string |
| http://purl.uniprot.org/citations/29587144 | http://purl.uniprot.org/core/title | "Nutritional Control of Stem Cell Division through S-Adenosylmethionine in Drosophila Intestine."xsd:string |
| http://purl.uniprot.org/citations/29587144 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/29587144 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29587144 |
| http://purl.uniprot.org/citations/29587144 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29587144 |
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