| http://purl.uniprot.org/citations/29589160 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29589160 | http://www.w3.org/2000/01/rdf-schema#comment | "Psoriasis vulgaris (PsV) is a common, chronic skin disease with a complex genetic and environmental etiology. We investigated, in 461 psoriatic patients and 454 healthy controls, the associations with psoriasis of four single-nucleotide polymorphisms (SNPs) from the psoriasis susceptibility 1 (PSORS1) interval: rs1062470 (PSORS1C1/CDSN), rs887466 (PSORS1C3), rs2894207 and rs10484554 (LOC105375015). The minor alleles of three SNPs (rs1062470A, rs2894207C and rs10484554T) strongly increased the disease risk (OR = 2.17, p < 0.0001; OR = 2.33, p < 0.0001 and OR = 2.68, p < 0.0001, respectively), whereas the minor A allele of rs887466 exerted a protective effect (OR = 0.73, p = 0.001). The strength of association for SNPs was the highest in patients with very early onset psoriasis (≤ 20 years), while in late onset psoriasis (> 40 years) the association was the weakest. The haplotype rs1062470A/rs887466G/rs2894207C/rs10484554T highly significantly increased the disease risk (OR = 3.58, p = 8.0e-027), while the haplotypes rs1062470G/rs887466A/rs2894207T/rs10484554C and rs1062470G/rs887466G/rs2894207T/rs10484554C were strongly protective (OR = 0.65, p = 0.002 and OR = 0.55, p = 2.4e-009, respectively). Additionally, we showed a HLA-C*06:02-independent gender-related effect of the rs887466A allele which was protective against psoriasis in males (OR = 0.61, p = 9.2e-005), but not in females (p = 0.66). We also demonstrated a correlation of PASI score value with rs1062470 genotype, and again only in male patients (p = 0.006) and HLA-C*06:02-independent. Our results show, for the first time, the male-only associations of the PSORS1C3 gene with psoriasis risk and of the PSORS1C1/CDSN gene with severity of disease. However, the age dependent associations need to be validated in larger sample sizes as well as in other populations."xsd:string |
| http://purl.uniprot.org/citations/29589160 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00438-018-1435-4"xsd:string |
| http://purl.uniprot.org/citations/29589160 | http://purl.uniprot.org/core/author | "Szczerkowska-Dobosz A."xsd:string |
| http://purl.uniprot.org/citations/29589160 | http://purl.uniprot.org/core/author | "Nowak I."xsd:string |
| http://purl.uniprot.org/citations/29589160 | http://purl.uniprot.org/core/author | "Wisniewski A."xsd:string |
| http://purl.uniprot.org/citations/29589160 | http://purl.uniprot.org/core/author | "Kusnierczyk P."xsd:string |
| http://purl.uniprot.org/citations/29589160 | http://purl.uniprot.org/core/author | "Matusiak L."xsd:string |
| http://purl.uniprot.org/citations/29589160 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29589160 | http://purl.uniprot.org/core/name | "Mol Genet Genomics"xsd:string |
| http://purl.uniprot.org/citations/29589160 | http://purl.uniprot.org/core/pages | "957-966"xsd:string |
| http://purl.uniprot.org/citations/29589160 | http://purl.uniprot.org/core/title | "HLA-C*06:02-independent, gender-related association of PSORS1C3 and PSORS1C1/CDSN single-nucleotide polymorphisms with risk and severity of psoriasis."xsd:string |
| http://purl.uniprot.org/citations/29589160 | http://purl.uniprot.org/core/volume | "293"xsd:string |
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