| http://purl.uniprot.org/citations/29593265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29593265 | http://www.w3.org/2000/01/rdf-schema#comment | "Medullary thymic epithelial cells (mTEC) purge the T cell repertoire of autoreactive thymocytes. Although dendritic cells (DC) reinforce this process by transporting innocuous peripheral self-antigens, the mechanisms that control their thymic entry remain unclear. Here we show that mTEC-CD4+ thymocyte crosstalk regulates the thymus homing of SHPS-1+ conventional DCs (cDC), plasmacytoid DCs (pDC) and macrophages. This homing process is controlled by lymphotoxin α (LTα), which negatively regulates CCL2, CCL8 and CCL12 chemokines in mTECs. Consequently, Ltα-deficient mice have increased expression of these chemokines that correlates with augmented classical NF-κB subunits and increased thymic recruitment of cDCs, pDCs and macrophages. This enhanced migration depends mainly on the chemokine receptor CCR2, and increases thymic clonal deletion. Altogether, this study identifies a fine-tuning mechanism of T cell repertoire selection and paves the way for therapeutic interventions to treat autoimmune disorders."xsd:string |
| http://purl.uniprot.org/citations/29593265 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-03619-9"xsd:string |
| http://purl.uniprot.org/citations/29593265 | http://purl.uniprot.org/core/author | "Irla M."xsd:string |
| http://purl.uniprot.org/citations/29593265 | http://purl.uniprot.org/core/author | "Serge A."xsd:string |
| http://purl.uniprot.org/citations/29593265 | http://purl.uniprot.org/core/author | "Lopes N."xsd:string |
| http://purl.uniprot.org/citations/29593265 | http://purl.uniprot.org/core/author | "Cedile O."xsd:string |
| http://purl.uniprot.org/citations/29593265 | http://purl.uniprot.org/core/author | "Charaix J."xsd:string |
| http://purl.uniprot.org/citations/29593265 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29593265 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/29593265 | http://purl.uniprot.org/core/pages | "1262"xsd:string |
| http://purl.uniprot.org/citations/29593265 | http://purl.uniprot.org/core/title | "Lymphotoxin alpha fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells."xsd:string |
| http://purl.uniprot.org/citations/29593265 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/29593265 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29593265 |
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