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http://purl.uniprot.org/citations/29594988http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Objective

This study aims to investigate the association between human leucocyte antigen (HLA)-DQB1 allele polymorphisms and the presence dental caries among the Uygur and Han children in Xinjiang.

Methods

HLA-DQB1 allele in the Uygur and Han children with dental caries and healthy control in Xinjiang was tested (n=40) using the polymerase chain reaction-sequence specific primer (PCR-SSP) DNA parting technology.

Results

A total of five specific loci were detected in the HLA-DQB1 locus among the Uygur and Han children. The frequency of the HLA-DQB1*02 allele in the Han group with severe caries (12.5%) was significantly lower than in the control group (32.5%) (P<0.05, OR=0.297). Moreover, the frequency of the HLA-DQB1*05 allele in the Uygur group with severe caries (37.5%) was significantly higher than in the control group (17.5%) (P<0.05, OR=2.829).

Conclusions

Caries susceptibility among the Uygur and Han children in Xinjiang is related to the HLA-DQB1 allele. The HLA-DQB1*02 allele may protect against caries among the Han children, whereas the HLA-DQB1*05 allele may be responsible for the susceptibility of the Uygur children to caries."xsd:string
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http://purl.uniprot.org/citations/29594988http://purl.uniprot.org/core/author"Liping W."xsd:string
http://purl.uniprot.org/citations/29594988http://purl.uniprot.org/core/author"Ruihan Z."xsd:string
http://purl.uniprot.org/citations/29594988http://purl.uniprot.org/core/author"Xiaobing L."xsd:string
http://purl.uniprot.org/citations/29594988http://purl.uniprot.org/core/author"Yishan L."xsd:string
http://purl.uniprot.org/citations/29594988http://purl.uniprot.org/core/date"2018"xsd:gYear
http://purl.uniprot.org/citations/29594988http://purl.uniprot.org/core/name"Hua Xi Kou Qiang Yi Xue Za Zhi"xsd:string
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http://purl.uniprot.org/citations/29594988http://purl.uniprot.org/core/title"[Association between the dental caries and the human leucocyte antigen DQB1 allele polymorphisms among the Uygur and Han children in Xinjiang]."xsd:string
http://purl.uniprot.org/citations/29594988http://purl.uniprot.org/core/volume"36"xsd:string
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