| http://purl.uniprot.org/citations/29599245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29599245 | http://www.w3.org/2000/01/rdf-schema#comment | "The integrated stress response (ISR) is a conserved translational and transcriptional program affecting metabolism, memory, and immunity. The ISR is mediated by stress-induced phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) that attenuates the guanine nucleotide exchange factor eIF2B. A chemical inhibitor of the ISR, ISRIB, reverses the attenuation of eIF2B by phosphorylated eIF2α, protecting mice from neurodegeneration and traumatic brain injury. We describe a 4.1-angstrom-resolution cryo-electron microscopy structure of human eIF2B with an ISRIB molecule bound at the interface between the β and δ regulatory subunits. Mutagenesis of residues lining this pocket altered the hierarchical cellular response to ISRIB analogs in vivo and ISRIB binding in vitro. Our findings point to a site in eIF2B that can be exploited by ISRIB to regulate translation."xsd:string |
| http://purl.uniprot.org/citations/29599245 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aar5129"xsd:string |
| http://purl.uniprot.org/citations/29599245 | http://purl.uniprot.org/core/author | "Fischer P.M."xsd:string |
| http://purl.uniprot.org/citations/29599245 | http://purl.uniprot.org/core/author | "Warren A.J."xsd:string |
| http://purl.uniprot.org/citations/29599245 | http://purl.uniprot.org/core/author | "Harding H.P."xsd:string |
| http://purl.uniprot.org/citations/29599245 | http://purl.uniprot.org/core/author | "Sekine Y."xsd:string |
| http://purl.uniprot.org/citations/29599245 | http://purl.uniprot.org/core/author | "Ron D."xsd:string |
| http://purl.uniprot.org/citations/29599245 | http://purl.uniprot.org/core/author | "Weis F."xsd:string |
| http://purl.uniprot.org/citations/29599245 | http://purl.uniprot.org/core/author | "Crespillo-Casado A."xsd:string |
| http://purl.uniprot.org/citations/29599245 | http://purl.uniprot.org/core/author | "Faille A."xsd:string |
| http://purl.uniprot.org/citations/29599245 | http://purl.uniprot.org/core/author | "Fromont C."xsd:string |
| http://purl.uniprot.org/citations/29599245 | http://purl.uniprot.org/core/author | "Parts L."xsd:string |
| http://purl.uniprot.org/citations/29599245 | http://purl.uniprot.org/core/author | "Allen F."xsd:string |
| http://purl.uniprot.org/citations/29599245 | http://purl.uniprot.org/core/author | "Zyryanova A.F."xsd:string |
| http://purl.uniprot.org/citations/29599245 | http://purl.uniprot.org/core/author | "Alard A.A."xsd:string |
| http://purl.uniprot.org/citations/29599245 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29599245 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/29599245 | http://purl.uniprot.org/core/pages | "1533-1536"xsd:string |
| http://purl.uniprot.org/citations/29599245 | http://purl.uniprot.org/core/title | "Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B."xsd:string |
| http://purl.uniprot.org/citations/29599245 | http://purl.uniprot.org/core/volume | "359"xsd:string |
| http://purl.uniprot.org/citations/29599245 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29599245 |
| http://purl.uniprot.org/citations/29599245 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29599245 |
| http://purl.uniprot.org/uniprot/#_Q14232-mappedCitation-29599245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29599245 |
| http://purl.uniprot.org/uniprot/#_Q13144-mappedCitation-29599245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29599245 |