DESCRIBE <http://purl.uniprot.org/citations/29599309>

Subject	Predicate	Object
http://purl.uniprot.org/citations/29599309	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/29599309	http://www.w3.org/2000/01/rdf-schema#comment	" Background/aim Pancreatic cancer is one of the most threatening and poorly understood human malignancies. MEKK3 (MAP3K3) is a serine/threonine kinase activated by different signaling pathways. YAP and TAZ are critical oncogenic effectors in pancreatic cancer. We hypothesized that MEKK3 could sustain pancreatic cancer by inducing YAP/TAZ oncogenic activities. Materials and methods In Panc1 and AsPC1 pancreatic cancer cell lines MEKK3 was knocked-out (KO) by the CRISPR/Cas9 method. These cells were used to evaluate MEKK3 contribution to the expression of YAP/TAZ and their target genes, cell migration, stemness, and in vivo tumor growth. Results MEKK3 KO reduced both EMT and cell migration, the size of 3D colonies and the percentage of CD44+/CD24+/EpCAM+ CSC, promoter recruitment of YAP/TAZ and the expression of their target genes. It reduced tumor growth and prolonged mice overall survival. Conclusion Silencing of MEKK3 represents a valid approach to revert in vivo the aggressiveness of pancreatic cancer by modulating YAP/TAZ transcriptional activities."xsd:string
http://purl.uniprot.org/citations/29599309	http://purl.org/dc/terms/identifier	"doi:10.21873/anticanres.12431"xsd:string
http://purl.uniprot.org/citations/29599309	http://purl.uniprot.org/core/author	"Piro G."xsd:string
http://purl.uniprot.org/citations/29599309	http://purl.uniprot.org/core/author	"Santoro R."xsd:string
http://purl.uniprot.org/citations/29599309	http://purl.uniprot.org/core/author	"Tortora G."xsd:string
http://purl.uniprot.org/citations/29599309	http://purl.uniprot.org/core/author	"Carbone C."xsd:string
http://purl.uniprot.org/citations/29599309	http://purl.uniprot.org/core/author	"Melisi D."xsd:string
http://purl.uniprot.org/citations/29599309	http://purl.uniprot.org/core/author	"Zanotto M."xsd:string
http://purl.uniprot.org/citations/29599309	http://purl.uniprot.org/core/date	"2018"xsd:gYear
http://purl.uniprot.org/citations/29599309	http://purl.uniprot.org/core/name	"Anticancer Res"xsd:string
http://purl.uniprot.org/citations/29599309	http://purl.uniprot.org/core/pages	"1937-1946"xsd:string
http://purl.uniprot.org/citations/29599309	http://purl.uniprot.org/core/title	"MEKK3 Sustains EMT and Stemness in Pancreatic Cancer by Regulating YAP and TAZ Transcriptional Activity."xsd:string
http://purl.uniprot.org/citations/29599309	http://purl.uniprot.org/core/volume	"38"xsd:string
http://purl.uniprot.org/citations/29599309	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/29599309
http://purl.uniprot.org/citations/29599309	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/29599309
http://purl.uniprot.org/uniprot/#_J3KRN4-mappedCitation-29599309	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/29599309
http://purl.uniprot.org/uniprot/#_Q1PBM3-mappedCitation-29599309	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/29599309
http://purl.uniprot.org/uniprot/#_Q9GZV5-mappedCitation-29599309	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/29599309
http://purl.uniprot.org/uniprot/#_Q99759-mappedCitation-29599309	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/29599309
http://purl.uniprot.org/uniprot/#_Q7Z4E6-mappedCitation-29599309	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/29599309
http://purl.uniprot.org/uniprot/#_Q96HN9-mappedCitation-29599309	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/29599309
http://purl.uniprot.org/uniprot/Q99759	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/29599309
http://purl.uniprot.org/uniprot/Q9GZV5	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/29599309
http://purl.uniprot.org/uniprot/Q96HN9	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/29599309