http://purl.uniprot.org/citations/29604594 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/29604594 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundRecent studies highlight the crucial regulatory roles of long non-coding RNAs (lncRNAs) in carcinogenesis. However, involvement of the lncRNA SNHG20 in cervical cancer progression remains unclear.MethodsThe expression of SNHG20 and miR-140-5p was determined in cervical cancer. Gain or loss of function assays were used to explore the roles of SNHG20 and miR-140-5p in cervical cancer cells. Luciferase assay and Western blot were used to explore the underlying mechanisms of SNHG20 and miR-140-5p in cervical cancer progression.ResultsQRT-PCR showed that SNHG20 expression was significantly increased in cervical cancer. MiR-140-5p acted as a downstream target of SNHG20. SNHG20 inhibition or miR-140-5p overexpression reduced cervical cancer cells proliferation and invasion ability. Furthermore, we identified that ADAM10 could act as a potential target of miR-140-5p. MEK/ERK signaling could be inhibited by miR-140-5p mimics in cervical cancer cells. In addition, ADAM10 overexpression abrogated the effect of miR-140-5p mimics on cervical cancer cells proliferation and invasion.ConclusionsOur study demonstrated that SNHG20 could function as an oncogenic lncRNA by regulating miR-140-5p-ADAM10 axis and MEK/ERK signaling pathway in cervical cancer."xsd:string |
http://purl.uniprot.org/citations/29604594 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.biopha.2018.03.024"xsd:string |
http://purl.uniprot.org/citations/29604594 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
http://purl.uniprot.org/citations/29604594 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
http://purl.uniprot.org/citations/29604594 | http://purl.uniprot.org/core/author | "Guo H."xsd:string |
http://purl.uniprot.org/citations/29604594 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
http://purl.uniprot.org/citations/29604594 | http://purl.uniprot.org/core/author | "Yang S."xsd:string |
http://purl.uniprot.org/citations/29604594 | http://purl.uniprot.org/core/author | "Yan M."xsd:string |
http://purl.uniprot.org/citations/29604594 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
http://purl.uniprot.org/citations/29604594 | http://purl.uniprot.org/core/name | "Biomed Pharmacother"xsd:string |
http://purl.uniprot.org/citations/29604594 | http://purl.uniprot.org/core/pages | "749-757"xsd:string |
http://purl.uniprot.org/citations/29604594 | http://purl.uniprot.org/core/title | "LncRNA SNHG20 promotes cell proliferation and invasion via miR-140-5p-ADAM10 axis in cervical cancer."xsd:string |
http://purl.uniprot.org/citations/29604594 | http://purl.uniprot.org/core/volume | "102"xsd:string |
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