| http://purl.uniprot.org/citations/29611806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29611806 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA replication transforms cohesin rings dynamically associated with chromatin into the cohesive form to establish sister-chromatid cohesion. Here, we show that, in human cells, cohesin loading onto chromosomes during early S phase requires the replicative helicase MCM2-7 and the kinase DDK. Cohesin and its loader SCC2/4 (NIPBL/MAU2 in humans) associate with DDK and phosphorylated MCM2-7. This binding does not require MCM2-7 activation by CDC45 and GINS, but its persistence on activated MCM2-7 requires fork-stabilizing replisome components. Inactivation of these replisome components impairs cohesin loading and causes interphase cohesion defects. Interfering with Okazaki fragment processing or nucleosome assembly does not impact cohesion. Therefore, MCM2-7-coupled cohesin loading promotes cohesion establishment, which occurs without Okazaki fragment maturation. We propose that the cohesin-loader complex bound to MCM2-7 is mobilized upon helicase activation, transiently held by the replisome, and deposited behind the replication fork to encircle sister chromatids and establish cohesion."xsd:string |
| http://purl.uniprot.org/citations/29611806 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.33920"xsd:string |
| http://purl.uniprot.org/citations/29611806 | http://purl.uniprot.org/core/author | "Yu H."xsd:string |
| http://purl.uniprot.org/citations/29611806 | http://purl.uniprot.org/core/author | "Zheng G."xsd:string |
| http://purl.uniprot.org/citations/29611806 | http://purl.uniprot.org/core/author | "Xing C."xsd:string |
| http://purl.uniprot.org/citations/29611806 | http://purl.uniprot.org/core/author | "Kanchwala M."xsd:string |
| http://purl.uniprot.org/citations/29611806 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29611806 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/29611806 | http://purl.uniprot.org/core/pages | "e33920"xsd:string |
| http://purl.uniprot.org/citations/29611806 | http://purl.uniprot.org/core/title | "MCM2-7-dependent cohesin loading during S phase promotes sister-chromatid cohesion."xsd:string |
| http://purl.uniprot.org/citations/29611806 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/29611806 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29611806 |
| http://purl.uniprot.org/citations/29611806 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29611806 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z441-mappedCitation-29611806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29611806 |
| http://purl.uniprot.org/uniprot/#_A8K2T2-mappedCitation-29611806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29611806 |
| http://purl.uniprot.org/uniprot/#_A0A590UJS4-mappedCitation-29611806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29611806 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4A5-mappedCitation-29611806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29611806 |
| http://purl.uniprot.org/uniprot/#_A0A384MTU6-mappedCitation-29611806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29611806 |
| http://purl.uniprot.org/uniprot/#_B3KUD7-mappedCitation-29611806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29611806 |
| http://purl.uniprot.org/uniprot/#_B4DDF5-mappedCitation-29611806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29611806 |
| http://purl.uniprot.org/uniprot/#_A6QL62-mappedCitation-29611806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29611806 |
| http://purl.uniprot.org/uniprot/#_A2RRA7-mappedCitation-29611806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29611806 |
| http://purl.uniprot.org/uniprot/#_B2R6V2-mappedCitation-29611806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29611806 |
| http://purl.uniprot.org/uniprot/#_B2RBA6-mappedCitation-29611806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29611806 |