| http://purl.uniprot.org/citations/29611821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29611821 | http://www.w3.org/2000/01/rdf-schema#comment | "Uncontrolled secretion of type I IFN, as the result of endosomal TLR (i.e., TLR7 and TLR9) signaling in plasmacytoid DCs (pDCs), and abnormal production of autoantibodies by B cells are critical for systemic lupus erythematosus (SLE) pathogenesis. The importance of galectin-9 (Gal-9) in regulating various autoimmune diseases, including lupus, has been demonstrated. However, the precise mechanism by which Gal-9 mediates this effect remains unclear. Here, using spontaneous murine models of lupus (i.e., BXSB/MpJ and NZB/W F1 mice), we demonstrate that administration of Gal-9 results in reduced TLR7-mediated autoimmune manifestations. While investigating the mechanism underlying this phenomenon, we observed that Gal-9 inhibits the phenotypic maturation of pDCs and B cells and abrogates their ability to mount cytokine responses to TLR7/TLR9 ligands. Importantly, immunocomplex-mediated (IC-mediated) and neutrophil extracellular trap-mediated (NET-mediated) pDC activation was inhibited by Gal-9. Additionally, the mTOR/p70S6K pathway, which is recruited by both pDCs and B cells for TLR-mediated IFN secretion and autoantibody generation, respectively, was attenuated. Gal-9 was found to exert its inhibitory effect on both the cells by interacting with CD44."xsd:string |
| http://purl.uniprot.org/citations/29611821 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci97333"xsd:string |
| http://purl.uniprot.org/citations/29611821 | http://purl.uniprot.org/core/author | "Panda S.K."xsd:string |
| http://purl.uniprot.org/citations/29611821 | http://purl.uniprot.org/core/author | "Liu Y.J."xsd:string |
| http://purl.uniprot.org/citations/29611821 | http://purl.uniprot.org/core/author | "Facchinetti V."xsd:string |
| http://purl.uniprot.org/citations/29611821 | http://purl.uniprot.org/core/author | "Kolbeck R."xsd:string |
| http://purl.uniprot.org/citations/29611821 | http://purl.uniprot.org/core/author | "Hanabuchi S."xsd:string |
| http://purl.uniprot.org/citations/29611821 | http://purl.uniprot.org/core/author | "Sanjuan M.A."xsd:string |
| http://purl.uniprot.org/citations/29611821 | http://purl.uniprot.org/core/author | "Hanna R.N."xsd:string |
| http://purl.uniprot.org/citations/29611821 | http://purl.uniprot.org/core/author | "Ettinger R."xsd:string |
| http://purl.uniprot.org/citations/29611821 | http://purl.uniprot.org/core/author | "Voynova E."xsd:string |
| http://purl.uniprot.org/citations/29611821 | http://purl.uniprot.org/core/author | "Karnell J.L."xsd:string |
| http://purl.uniprot.org/citations/29611821 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29611821 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/29611821 | http://purl.uniprot.org/core/pages | "1873-1887"xsd:string |
| http://purl.uniprot.org/citations/29611821 | http://purl.uniprot.org/core/title | "Galectin-9 inhibits TLR7-mediated autoimmunity in murine lupus models."xsd:string |
| http://purl.uniprot.org/citations/29611821 | http://purl.uniprot.org/core/volume | "128"xsd:string |
| http://purl.uniprot.org/citations/29611821 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29611821 |
| http://purl.uniprot.org/citations/29611821 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29611821 |
| http://purl.uniprot.org/uniprot/#_A2AHJ1-mappedCitation-29611821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29611821 |
| http://purl.uniprot.org/uniprot/#_A2AHJ2-mappedCitation-29611821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29611821 |
| http://purl.uniprot.org/uniprot/#_B1AQR8-mappedCitation-29611821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29611821 |
| http://purl.uniprot.org/uniprot/#_P58681-mappedCitation-29611821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29611821 |
| http://purl.uniprot.org/uniprot/#_G3X9T7-mappedCitation-29611821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29611821 |