| http://purl.uniprot.org/citations/29614685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29614685 | http://www.w3.org/2000/01/rdf-schema#comment | "Impairment of cerebral glucose uptake/metabolism in individuals with Alzheimer's disease (AD) is believed to lead to downregulation of protein O-GlcNAcylation, which contributes to tau pathogenesis through tau hyperphosphorylation. Level of glucose transporter 3 (GLUT3), a neuronal specific glucose transporter, is decreased in AD brain, which may contribute to impaired brain glucose uptake/metabolism. However, what causes the reduction of GLUT3 in AD brain is not fully understood. Here, we report 1) that decrease of GLUT3 is associated with the reduction of protein O-GlcNAcylation in AD brain, 2) that GLUT3 level is negatively correlated with calpain I activation in human brain, 3) that calpain I proteolyzes GLUT3 at the N-terminus in vitro, and 4) that activation of calpain I is negatively correlated with protein O-GlcNAcylation in AD brain. Furthermore, we found that overexpression of GLUT3 enhances protein O-GlcNAcylation in N2a cells. Overexpression of calpain I suppresses protein O-GlcNAcylation in these cells. These findings suggest a novel mechanism by which calpain I overactivation leads to GLUT3 degradation and the consequent down-regulation of protein O-GlcNAcylation in AD brain."xsd:string |
| http://purl.uniprot.org/citations/29614685 | http://purl.org/dc/terms/identifier | "doi:10.3233/jad-171047"xsd:string |
| http://purl.uniprot.org/citations/29614685 | http://purl.uniprot.org/core/author | "Gu J."xsd:string |
| http://purl.uniprot.org/citations/29614685 | http://purl.uniprot.org/core/author | "Liu F."xsd:string |
| http://purl.uniprot.org/citations/29614685 | http://purl.uniprot.org/core/author | "Ma D."xsd:string |
| http://purl.uniprot.org/citations/29614685 | http://purl.uniprot.org/core/author | "Jin N."xsd:string |
| http://purl.uniprot.org/citations/29614685 | http://purl.uniprot.org/core/author | "Iqbal K."xsd:string |
| http://purl.uniprot.org/citations/29614685 | http://purl.uniprot.org/core/author | "Chu D."xsd:string |
| http://purl.uniprot.org/citations/29614685 | http://purl.uniprot.org/core/author | "Gong C.X."xsd:string |
| http://purl.uniprot.org/citations/29614685 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29614685 | http://purl.uniprot.org/core/name | "J Alzheimers Dis"xsd:string |
| http://purl.uniprot.org/citations/29614685 | http://purl.uniprot.org/core/pages | "1737-1746"xsd:string |
| http://purl.uniprot.org/citations/29614685 | http://purl.uniprot.org/core/title | "Calpain I Activation Causes GLUT3 Proteolysis and Downregulation of O-GlcNAcylation in Alzheimer's Disease Brain."xsd:string |
| http://purl.uniprot.org/citations/29614685 | http://purl.uniprot.org/core/volume | "62"xsd:string |
| http://purl.uniprot.org/citations/29614685 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29614685 |
| http://purl.uniprot.org/citations/29614685 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29614685 |
| http://purl.uniprot.org/uniprot/#_P11169-mappedCitation-29614685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29614685 |
| http://purl.uniprot.org/uniprot/#_B2RDI5-mappedCitation-29614685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29614685 |
| http://purl.uniprot.org/uniprot/#_B4DWH5-mappedCitation-29614685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29614685 |
| http://purl.uniprot.org/uniprot/#_B7Z966-mappedCitation-29614685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29614685 |
| http://purl.uniprot.org/uniprot/#_O35350-mappedCitation-29614685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29614685 |
| http://purl.uniprot.org/uniprot/#_B7Z5A7-mappedCitation-29614685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29614685 |
| http://purl.uniprot.org/uniprot/#_Q3TI07-mappedCitation-29614685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29614685 |
| http://purl.uniprot.org/uniprot/#_P32037-mappedCitation-29614685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29614685 |