| http://purl.uniprot.org/citations/29614714 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29614714 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29614714 | http://www.w3.org/2000/01/rdf-schema#comment | "α-Conotoxins (α-CTxs) are small peptides composed of 11 to 20 amino acid residues with two disulfide bridges. Most of them potently and selectively target nicotinic acetylcholine receptor (nAChR) subtypes, and a few were found to inhibit the GABAB receptor (GABABR)-coupled N-type calcium channels (Cav2.2). However, in all of α-CTxs targeting both receptors, the disulfide connectivity arrangement "C¹-C³, C²-C⁴" is present. In this work, a novel α4/7-CTx named Lt1.3 (GCCSHPACSGNNPYFC-NH₂) was cloned from the venom ducts of Conus litteratus (C. litteratus) in the South China Sea. Lt1.3 was then chemically synthesized and two isomers with disulfide bridges "C¹-C³, C²-C⁴" and "C¹-C⁴, C²-C³" were found and functionally characterized. Electrophysiological experiments showed that Lt1.3 containing the common disulfide bridges "C¹-C³, C²-C⁴" potently and selectively inhibited α3β2 nAChRs and not GABABR-coupled Cav2.2. Surprisingly, but the isomer with the disulfide bridges "C¹-C⁴, C²-C³" showed exactly the opposite inhibitory activity, inhibiting only GABABR-coupled Cav2.2 and not α3β2 nAChRs. These findings expand the knowledge of the targets and selectivity of α-CTxs and provide a new structural motif to inhibit the GABABR-coupled Cav2.2."xsd:string |
| http://purl.uniprot.org/citations/29614714 | http://purl.org/dc/terms/identifier | "doi:10.3390/md16040112"xsd:string |
| http://purl.uniprot.org/citations/29614714 | http://purl.org/dc/terms/identifier | "doi:10.3390/md16040112"xsd:string |
| http://purl.uniprot.org/citations/29614714 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/29614714 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/29614714 | http://purl.uniprot.org/core/author | "Cai F."xsd:string |
| http://purl.uniprot.org/citations/29614714 | http://purl.uniprot.org/core/author | "Cai F."xsd:string |
| http://purl.uniprot.org/citations/29614714 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/29614714 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/29614714 | http://purl.uniprot.org/core/author | "Zhou L."xsd:string |
| http://purl.uniprot.org/citations/29614714 | http://purl.uniprot.org/core/author | "Zhou L."xsd:string |
| http://purl.uniprot.org/citations/29614714 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/29614714 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/29614714 | http://purl.uniprot.org/core/author | "Dai Q."xsd:string |
| http://purl.uniprot.org/citations/29614714 | http://purl.uniprot.org/core/author | "Dai Q."xsd:string |
| http://purl.uniprot.org/citations/29614714 | http://purl.uniprot.org/core/author | "Liang L."xsd:string |
| http://purl.uniprot.org/citations/29614714 | http://purl.uniprot.org/core/author | "Liang L."xsd:string |
| http://purl.uniprot.org/citations/29614714 | http://purl.uniprot.org/core/author | "Ning H."xsd:string |
| http://purl.uniprot.org/citations/29614714 | http://purl.uniprot.org/core/author | "Ning H."xsd:string |
| http://purl.uniprot.org/citations/29614714 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29614714 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29614714 | http://purl.uniprot.org/core/name | "Mar. Drugs"xsd:string |
| http://purl.uniprot.org/citations/29614714 | http://purl.uniprot.org/core/name | "Mar. Drugs"xsd:string |