| http://purl.uniprot.org/citations/29615610 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29615610 | http://www.w3.org/2000/01/rdf-schema#comment | "Drugs of abuse, including alcohol, ablate the expression of specific forms of long-term synaptic depression (LTD) at glutamatergic synapses in dorsal striatum (DS), a brain region involved in goal-directed and habitual behaviors. This loss of LTD is associated with altered DS-dependent behavior. Given the role of the µ-opioid receptor (MOR) in behavioral responding for alcohol, we explored the impact of alcohol on various forms of MOR-mediated synaptic depression that we find are differentially expressed at specific DS synapses. Corticostriatal MOR-mediated LTD (mOP-LTD) in the dorsolateral striatum occurs exclusively at inputs from anterior insular cortex and is selectively disrupted by in vivo alcohol exposure. Alcohol has no effect on corticostriatal mOP-LTD in dorsomedial striatum, thalamostriatal MOR-mediated short-term depression, or mOP-LTD of cholinergic interneuron-driven glutamate release. Disrupted mOP-LTD at anterior insular cortex-dorsolateral striatum synapses may therefore be a key mechanism of alcohol-induced neuroadaptations involved in the development of alcohol use disorders."xsd:string |
| http://purl.uniprot.org/citations/29615610 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-03683-1"xsd:string |
| http://purl.uniprot.org/citations/29615610 | http://purl.uniprot.org/core/author | "Yin F."xsd:string |
| http://purl.uniprot.org/citations/29615610 | http://purl.uniprot.org/core/author | "Munoz B."xsd:string |
| http://purl.uniprot.org/citations/29615610 | http://purl.uniprot.org/core/author | "Atwood B.K."xsd:string |
| http://purl.uniprot.org/citations/29615610 | http://purl.uniprot.org/core/author | "Fritz B.M."xsd:string |
| http://purl.uniprot.org/citations/29615610 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29615610 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/29615610 | http://purl.uniprot.org/core/pages | "1318"xsd:string |
| http://purl.uniprot.org/citations/29615610 | http://purl.uniprot.org/core/title | "Alcohol exposure disrupts mu opioid receptor-mediated long-term depression at insular cortex inputs to dorsolateral striatum."xsd:string |
| http://purl.uniprot.org/citations/29615610 | http://purl.uniprot.org/core/volume | "9"xsd:string |
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