| http://purl.uniprot.org/citations/29615682 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29615682 | http://www.w3.org/2000/01/rdf-schema#comment | "The S100A2 protein is an important regulator of keratinocyte differentiation, but its role in wound healing remains unknown. We establish epithelial-specific S100A2 transgenic (TG) mice and study its role in wound repair using punch biopsy wounding assays. In line with the observed increase in proliferation and migration of S100A2-depleted human keratinocytes, mice expressing human S100A2 exhibit delayed cutaneous wound repair. This was accompanied by the reduction of re-epithelialization as well as a slow, attenuated response of Mcp1, Il6, Il1β, Cox2, and Tnf mRNA expression in the early phase. We also observed delayed Vegfa mRNA induction, a delayed enhancement of the Tgfβ1-mediated alpha smooth muscle actin (α-Sma) axis and a differential expression of collagen type 1 and 3. The stress-activated p53 tumor suppressor protein plays an important role in cutaneous wound healing and is an S100A2 inducer. Notably, S100A2 complexes with p53, potentiates p53-mediated transcription and increases p53 expression both transcriptionally and posttranscriptionally. Consistent with a role of p53 in repressing NF-κB-mediated transcriptional activation, S100A2 enhanced p53-mediated promoter suppression of Cox2, an early inducible NF-κB target gene upon wound injury. Our study thus supports a model in which the p53-S100A2 positive feedback loop regulates wound repair process."xsd:string |
| http://purl.uniprot.org/citations/29615682 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-018-23697-5"xsd:string |
| http://purl.uniprot.org/citations/29615682 | http://purl.uniprot.org/core/author | "Li C.Y."xsd:string |
| http://purl.uniprot.org/citations/29615682 | http://purl.uniprot.org/core/author | "Huang Y.H."xsd:string |
| http://purl.uniprot.org/citations/29615682 | http://purl.uniprot.org/core/author | "Kao H.Y."xsd:string |
| http://purl.uniprot.org/citations/29615682 | http://purl.uniprot.org/core/author | "Kuo Y."xsd:string |
| http://purl.uniprot.org/citations/29615682 | http://purl.uniprot.org/core/author | "Tsai W.C."xsd:string |
| http://purl.uniprot.org/citations/29615682 | http://purl.uniprot.org/core/author | "Fang W.Y."xsd:string |
| http://purl.uniprot.org/citations/29615682 | http://purl.uniprot.org/core/author | "Kuo C.Y."xsd:string |
| http://purl.uniprot.org/citations/29615682 | http://purl.uniprot.org/core/author | "Wu L.W."xsd:string |
| http://purl.uniprot.org/citations/29615682 | http://purl.uniprot.org/core/author | "Hsieh T.C."xsd:string |
| http://purl.uniprot.org/citations/29615682 | http://purl.uniprot.org/core/author | "Pan S.C."xsd:string |
| http://purl.uniprot.org/citations/29615682 | http://purl.uniprot.org/core/author | "Tsai S.T."xsd:string |
| http://purl.uniprot.org/citations/29615682 | http://purl.uniprot.org/core/author | "Kang Y.R."xsd:string |
| http://purl.uniprot.org/citations/29615682 | http://purl.uniprot.org/core/author | "Kuo Y.Z."xsd:string |
| http://purl.uniprot.org/citations/29615682 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29615682 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/29615682 | http://purl.uniprot.org/core/pages | "5458"xsd:string |
| http://purl.uniprot.org/citations/29615682 | http://purl.uniprot.org/core/title | "The p53-S100A2 Positive Feedback Loop Negatively Regulates Epithelialization in Cutaneous Wound Healing."xsd:string |
| http://purl.uniprot.org/citations/29615682 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/29615682 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29615682 |
| http://purl.uniprot.org/citations/29615682 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29615682 |
| http://purl.uniprot.org/uniprot/#_A0A0A0U7X4-mappedCitation-29615682 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29615682 |
| http://purl.uniprot.org/uniprot/#_A0A0M4B4Y9-mappedCitation-29615682 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29615682 |